Clin Psychopharmacol Neurosci.  2017 Aug;15(3):288-291. 10.9758/cpn.2017.15.3.288.

Five Month-Persistent Extrapyramidal Symptoms following a Single Injection of Paliperidone Palmitate: A Case Report

  • 1Department of Psychiatry, Catholic University of Daegu School of Medicine, Daegu, Korea.
  • 2Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, Korea.


Long-acting injectable (LAI) antipsychotics are useful in the treatments for schizophrenic patients with poor adherence due to their maintaining feature of therapeutic plasma level without daily administrations. However, their long-lasting property can cause complicated problems such as a long-lasting side effect. We report a patient who experienced LAI-induced extrapyramidal symptoms (EPSs) for 5 months after a single injection. During that period, every trial to ameliorate this condition turned out to be a failure. The 3-month formulation of paliperidone palmitate is now close at hand. We have to be aware of possible long-lasting adverse events and confirm the tolerability to LAI before use.


Long-acting injectable antipsychotics; Paliperidone palmitate; Extrapyramidal symptoms; Schizophrenia
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