Korean J Schizophr Res.  2018 Oct;21(2):74-80. 10.16946/kjsr.2018.21.2.74.

Change in Cognitive Function after Antipsychotics Treatment : A Pilot Study of Long-Acting Injectable versus Oral Form

• Sung K
• Kim S
• Kim E

• KMID: 2423030
• DOI: http://doi.org/10.16946/kjsr.2018.21.2.74

Abstract

OBJECTIVES
This study investigated whether long-acting injectable (LAI) paliperidone is different from its oral form in terms of the effect on cognitive function in schizophrenia spectrum and other psychotic disorders.
METHODS
We reviewed the medical records of patients in Seoul National University Bundang Hospital who were diagnosed as having schizophrenia and/or other psychotic disorders based on DSM-5 from 2016 to 2017. Seven patients were treated with oral paliperidone and 11 were treated with paliperidone palmitate. All patients underwent clinical and neuropsychological assessment, including the Korean version of the MATRICS Consensus Cognitive Battery (MCCB) at their first visit or within one month of their initial treatment. MCCB was repeated within three to 12 months after the initial assessment.
RESULTS
There was no significant difference between the two groups in most cognitive domains including speed of processing, attention and vigilance, working memory, verbal learning, visual learning and reasoning and problem solving domain. However, patients treated with paliperidone palmitate showed better improvement in social cognition domain than those taking oral paliperidone. The standardized values of social cognition domain scores had significantly improved over time in patients under paliperidone palmitate, demonstrating a significant time-by-group interaction.
CONCLUSION
Our results show that long-acting injectable paliperidone could be helpful in some aspects of improving cognitive function in schizophrenia spectrum and other psychotic disorders. Further studies with other antipsychotics are necessary to generalize the results.

Keyword

Schizophrenia; Long-acting injectables; Cognitive function; Paliperidone

MeSH Terms

Antipsychotic Agents*
Cognition*
Consensus
Humans
Learning
Medical Records
Memory, Short-Term
Paliperidone Palmitate
Pilot Projects*
Problem Solving
Psychotic Disorders
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Seoul
Verbal Learning
Antipsychotic Agents
Paliperidone Palmitate

Figure

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  Fig. 1 Cognitive change with paliperidone versus paliperidone palmitate. (A) Composite score of MCCB before and after the treatment with paliperidone or paliperidone palmitate. (B) Social cognition of MCCB before and after the treatment with paliperidone or paliperidone palmitate.

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