Nat Prod Sci.  2017 Jun;23(2):97-102. 10.20307/nps.2017.23.2.97.

Acetylcholinesterase Inhibitors from Angelica polymorpha Stem

• Kwon Y
• Kim HP
• Kim MJ
• Chun W

• KMID: 2387058
• DOI: http://doi.org/10.20307/nps.2017.23.2.97

Abstract

Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin (5), geijerine (6), (−)-3'-acetyl hamaudol (7), 7-demethylsuberosine (8), dehydrogeijerin (9), (−)-hamaudol (10), (+)-visamminol (11), divaricatol (12), scopoletin (13), and decursidate (14), respectively. Among them, compounds 4 - 6, 8, 9, 13, and 14 were isolated for the first time from A. polymorpha. Dehydrogeijerin (6) and geijerin (9) were isolated for the first time from genus Angelica. All isolates tested for inhibitory activity against acetylcholinesterae. Compounds 1 to 13 showed acetylcholinesterase inhibitory activity with ICâ‚…â‚€ values ranging from 1.4 to 37.5 µM.

Keyword

Angelica polymorpha; Coumarins; Chromones; Acetylcholinesterase inhibitory effect

MeSH Terms

Acetylcholinesterase*
Angelica*
Cholinesterase Inhibitors*
Chromones
Coumarins
Scopoletin
Acetylcholinesterase
Cholinesterase Inhibitors
Chromones
Coumarins
Scopoletin

Figure

• 

  Fig. 1. Structures of 1 – 14.

Reference

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