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Acetylcholinesterase Inhibitors from Angelica polymorpha Stem

Kwon Y, Kim HP, Kim MJ, Chun W

Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin...
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Clinical Significance of Repetitive Compound Muscle Action Potentials in Patients with Myasthenia Gravis: A Predictor for Cholinergic Side Effects of Acetylcholinesterase Inhibitors

Lee HE, Kim YH, Kim SM, Shin HY

BACKGROUND AND PURPOSE: Acetylcholinesterase inhibitors (AChEIs) are widely used to treat myasthenia gravis (MG). Although AChEIs are usually tolerated well, some MG patients suffer from side effects. Furthermore, a small...
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Clinical and Electrophysiologic Responses to Acetylcholinesterase Inhibitors in MuSK-Antibody-Positive Myasthenia Gravis: Evidence for Cholinergic Neuromuscular Hyperactivity

Shin HY, Park HJ, Lee HE, Choi YC, Kim SM

BACKGROUND AND PURPOSE: Patients with muscle-specific tyrosine kinase (MuSK) antibody (MuSK-Ab)-positive myasthenia gravis (MG) show distinct responses to acetylcholinesterase inhibitors (AChEIs). Although clinical responses to AChEIs in MuSK-Ab MG are...
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Comparison of Antiallodynic Effects between Intrathecal Cholinesterase Inhibitors and NMDA Antagonists on Two Neuropathic Pain Rat Models

Kang KN, Cho SJ, Hwang JH

BACKGOUND: Cholinesterase inhibitors and N-methyl-D-aspartate (NMDA) antagonists reduce the mechanical allodynia in neuropathic pain models. In this study our aim was to compare the antiallodynic effects between intrathecal cholinesterase inhibitors...
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Two Cases of Discontinuation Syndrome Following Cessation of Cholinesterase Inhibitors

Kwak YT

  • KMID: 2343089
  • J Korean Neurol Assoc.
  • 2004 Aug;22(4):386-388.
Discontinuation syndrome is a cluster of symptoms that appear when a patient terminates long-term medication. We report 2 patients with Alzheimer's disease who developed significant behavioral disturbances after the cessation...
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Regional Cerebral Blood Flow Changes in Alzheimer's Disease Patients Treated with Cholinesterase Inhibitors: A Preliminary Study using 99mTC-ECD SPECT

Park MY, Cho I

  • KMID: 2195071
  • J Korean Neurol Assoc.
  • 2003 Jun;21(3):255-260.
BACKGROUND: This study aimed to evaluate regional cerebral blood flow (rCBF) changes using 99mTC-ECD SPECT (Ethylene Cysteine Diethylester Single Photon Emission Computed Tomography) and contemporary clinical responses such as cognitive...
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The Effect of 4-Aminopyridine with Anticholinesterases on MgSO4-Rocuronium-Induced Neuromuscular Blockade in Vitro

Hwang KH, Cho MH, Hong ST, Park W, Kim SY

BACKGROUND: The aim of this study was to evaluate the effect of 4-aminopyridine (4-AP) combined with anticholiesterase (antiChE) in antagonizing MgSO4-rocuronium-induced neuromuscualr blockade using a rat hemidiaphragm. METHODS: A hemidiaphragm with...
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The Effects of Anticholinesterase Drugs on Gastric Motility

Choi HC, Kim JH, Ha JH, Lee KY, Kim WJ, Kwak DS, Kim SH, Song PH, Yeo JH

  • KMID: 2320289
  • Yeungnam Univ J Med.
  • 1999 Dec;16(2):318-325.
BACKGROUND: Anticholinesterase drug inhibits acetylcholinesterase(AChE), induce accumulation of acetylcholine(ACh) near cholinergic receptors and cholinergic stimulation. This experiment was performed to study the effects of anticholinesterase drugs on gastric motility and...
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The Priming Principle with Anticholinesterases for the Recovery of Profound Muscle Relaxation

Kim KS, Han JU, Min YJ, Jeon JW, Lee ME, Jeon MS, Na DJ

The success of accelerating the onset of neuromvacular blocking drugs by giving them in divided doses encouraged others to attempt the same "priming principle" using reversal agents. Naguib et al...
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Effects of Anticholinesterases on the Neuromuscular Blocking Action of Suecinylcholine

Moon BK, Shin YS, Park KW, Cho CH

The interaction between succinylcholine (SCC) and anticholinegterase drugs is illustrated by the inhibition of acetylcholine hydrolysis or a decrease in pseudocholinesterase activity- The present study was performed in order to...
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