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Interruption of Helicobacter pylori-Induced NLRP3 Inflammasome Activation by Chalcone Derivatives

Choi HR, Lim H, Lee JH, Park H, Kim HP

Helicobacter pylori causes chronic gastritis through cag pathogenicity island (cagPAI), vacuolating cytotoxin A (VacA), lipopolysaccharides (LPS), and flagellin as pathogen-related molecular patterns (PAMPs), which, in combination with the pattern recognition...
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Potential Moracin M Prodrugs Strongly Attenuate Airway Inflammation In Vivo

Lee J, Mandava S, Ahn SH, Bae MA, So KS, Kwon KS, Kim HP

This study aims to develop new potential therapeutic moracin M prodrugs acting on lung inflammatory disorders. Potential moracin M prodrugs (KW01-KW07) were chemically synthesized to obtain potent orally active derivatives,...
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Flavonoids: Broad Spectrum Agents on Chronic Inflammation

Lim H, Heo MY, Kim HP

Flavonoids are major plant constituents with numerous biological/pharmacological actions both in vitro and in vivo. Of these actions, their anti-inflammatory action is prominent. They can regulate transcription of many proinflammatory...
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Anti-arthritic Effects of Oplopanax elatus in a Rat Model of Rheumatoid Arthritis (Adjuvant-induced Arthritis)

Kwon KS, Lim H, Kwon YS, Choi HR, Kim MJ, Yoo JH, Yoo NH, Kim HP

The stems of Oplopanax elatus (OE) have long been used to treat inflammatory disorders in herbal medicine, and in the previous investigation, OE was found to possess anti-inflammatory activity in...
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NFATC3–PLA2G15 Fusion Transcript Identified by RNA Sequencing Promotes Tumor Invasion and Proliferation in Colorectal Cancer Cell Lines

Jang JE, Kim HP, Han SW, Jang H, Lee SH, Song SH, Bang D, Kim TY

PURPOSE: This study was designed to identify novel fusion transcripts (FTs) and their functional significance in colorectal cancer (CRC) lines. MATERIALS AND METHODS: We performed paired-end RNA sequencing of 28 CRC...
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Therapeutic Potential of the Rhizomes of Anemarrhena asphodeloides and Timosaponin A-III in an Animal Model of Lipopolysaccharide-Induced Lung Inflammation

Park BK, So KS, Ko HJ, Kim HJ, Kwon KS, Kwon YS, Son KH, Kwon SY, Kim HP

Investigations into the development of new therapeutic agents for lung inflammatory disorders have led to the discovery of plant-based alternatives. The rhizomes of Anemarrhena asphodeloides have a long history of...
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A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots

Park SY, Lee N, Lee S, Kim MJ, Chun W, Kim HP, Yang HJ, Lee HS, Kwon Y

Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2),...
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CCCTC-binding factor is essential to the maintenance and quiescence of hematopoietic stem cells in mice

Kim TG, Kim S, Jung S, Kim M, Yang B, Lee MG, Kim HP

Hematopoiesis involves a series of lineage differentiation programs initiated in hematopoietic stem cells (HSCs) found in bone marrow (BM). To ensure lifelong hematopoiesis, various molecular mechanisms are needed to maintain...
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Acetylcholinesterase Inhibitors from Angelica polymorpha Stem

Kwon Y, Kim HP, Kim MJ, Chun W

Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin...
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Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

Kim HP, Lim H, Kwon YS

Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These...
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Identification of Diverse Adenosine-to-Inosine RNA Editing Subtypes in Colorectal Cancer

Lee SH, Kim HP, Kang JK, Song SH, Han SW, Kim TY

PURPOSE: RNA editing generates protein diversity by altering RNA sequences in coding regions without changing the overall DNA sequence. Adenosine-to-inosine (A-to-I) RNA editing events have recently been reported in some...
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Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-Specific Biomarker for Human Gastrointestinal Cancer

Jeon MS, Song SH, Yun J, Kang JY, Kim HP, Han SW, Kim TY

PURPOSE: Epigenetic alterations of specific genes have recently been identified as diagnostic biomarkers for human cancers. However, there are currently no standardized epigenetic biomarkers for drug sensitivity in human gastrointestinal...
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The New Phytoformula Containing Morus alba, Schizandra sinensis and Asparagus cochinchinensis Inhibits Lung Inflammation in vitro and in vivo

Jeong HG, Lee CW, Lee JH, Kim SJ, Kwon YS, Heo Y, Kim HP

A phytoformula containing the root barks of Morus alba, the fructus of Schizandra sinensis and the roots of Asparagus cochinchinensis (MSA) was prepared as a potential new herbal remedy, and...
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Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents

Lee JH, Sun YN, Kim YH, Lee SK, Kim HP

In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as...
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Lightening up Light Therapy: Activation of Retrograde Signaling Pathway by Photobiomodulation

Kim HP

Photobiomodulation utilizes monochromatic (or quasimonochromatic) light in the electromagnetic region of 600~1000 nm for the treatment of soft tissues in a nondestructive and nonthermal mode. It is conceivable that photobiomodulation...
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Ixodid Tick Infestation in Cattle and Wild Animals in Maswa and Iringa, Tanzania

Kwak YS, Kim TY, Nam SH, Lee IY, Kim HP, Mduma S, Keyyu J, Fyumagwa R, Yong TS

Ticks and tick-borne diseases are important in human and livestock health worldwide. In November 2012, ixodid ticks were collected and identified morphologically from cattle and wild animals in the Maswa...
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Inhibition of Proinflammatory Cytokine Generation in Lung Inflammation by the Leaves of Perilla frutescens and Its Constituents

Lim HJ, Woo KW, Lee KR, Lee SK, Kim HP

  • KMID: 2048332
  • Biomol Ther.
  • 2014 Jan;22(1):62-67.
This study was designed to find some potential natural products and/or constituents inhibiting proinflammatory cytokine generation in lung inflammation, since cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)...
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Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line

Lee YY, Kim HP, Kang MJ, Cho BK, Han SW, Kim TY, Yi EC

  • KMID: 2154283
  • Exp Mol Med.
  • 2013 Nov;45(11):e64.
Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinases, has shown promising results as a growth inhibitor of HER2-positive...
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Inhibition of Experimental Systemic Inflammation (Septic Inflammation) and Chronic Bronchitis by New Phytoformula BL Containing Broussonetia papyrifera and Lonicera japonica

Ko HJ, Kwon OS, Jin JH, Son KH, Kim HP

  • KMID: 2170688
  • Biomol Ther.
  • 2013 Jan;21(1):66-71.
Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of inflammatory disorders in Chinese medicine, especially respiratory inflammation. Previously, a new phytoformula (BL) containing B. papyrifera and...
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Evaluation of the Necessity of Port Fixation in Central Venous Port Implantation

Kim SS, Kim HP, Bae JI, Won JH

PURPOSE: The technical success and complications were especially focused on and evaluated the need for fixation of a port under fluoroscopic guidance placement of the totally implantable central venous access...
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