J Nutr Health.
2017 Jun;50(3):246-256. 10.4163/jnh.2017.50.3.246.
Association of total dietary antioxidant capacity with oxidative stress and metabolic markers among patients with metabolic syndrome
- Affiliations
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- 1Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea. hjjoung@snu.ac.kr
- 2Center for Gendered Innovations in Science and Technology Researches (GISTER), Korea Federation of Women's Science & Technology Associations, Seoul 06130, Korea.
- 3Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 03080, Korea.
- 4Department of Clinical Nutrition, Research Institute & Hospital, National Cancer Center, Goyang-si 10408, Korea.
- 5Department of Internal Medicine, Division of Gastroenterology & Clinical Nutrition, DMC Bundang Jesaeng Hospital, Seongnam-si 13590, Korea.
- 6Institute of Health and Environment, Seoul National University, Seoul 08826, Korea.
- KMID: 2386626
- DOI: http://doi.org/10.4163/jnh.2017.50.3.246
Abstract
- PURPOSE
This study aimed to investigate the association of total dietary antioxidant capacity (TAC) with oxidative stress and metabolic markers among patients with metabolic syndrome according to gender.
METHODS
A total of 346 subjects aged 30~59 years with two or more risk factors of metabolic syndrome were recruited from a general hospital near Seoul in South Korea between 2010 and 2012 based on data from the medical checkup. Biochemical indices for oxidative stress and metabolic markers were measured. Food consumption data from 3-day food records were linked with the antioxidant capacity database for commonly consumed Korean foods to estimate individual's TAC.
RESULTS
Average dietary TAC of the study subjects was 132.0 mg VCE/d/1,000 kcal in men and 196.4 mg VCE/d/1,000 kcal in women. Levels of γ-glutamyltransferase (GGT), systolic blood pressure, diastolic blood pressure, and blood triglycerides were reduced significantly according to increasing TAC in men, but there was no significant trend in women. Intakes of total flavonoids and carotenoids were significantly negatively correlated with GGT (p < 0.05) and d-ROMs (p < 0.01) in men, whereas those of α-tocopherol (p < 0.05) and γ-tocopherol (p < 0.05) were positively correlated with biological antioxidant potential (BAP) in women. The odds ratio of high oxidative stress indices and abnormal metabolic markers according to TAC level were not significant in either men or women.
CONCLUSION
The results show that dietary TAC was partially associated with oxidative stress and metabolic markers among patients with metabolic syndrome. Further research is required for elucidating the association between dietary TAC and incidence of metabolic syndrome and chronic diseases within a large population in prospective studies.
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