J Clin Neurol.  2016 Oct;12(4):393-402. 10.3988/jcn.2016.12.4.393.

The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group

Affiliations
  • 1Department of Neurology, Korea University College of Medicine, Seoul, Korea.
  • 2Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • 3Department of Neurology, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea.
  • 4Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.
  • 5Department of Neurology, Chung-Ang University College of Medicine, Seoul, Korea.
  • 6Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 7Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
  • 8Department of Neurology, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea.
  • 9Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.
  • 10Department of Neurology, Presbyterian Medical Center, Jeonju, Korea.
  • 11Department of Neurology, College of Medicine, Inje University Seoul Paik Hospital, Seoul, Korea.
  • 12Department of Neurology, University of Ulsan College of Medicine, Asan Hospital, Seoul, Korea.
  • 13Department of Neurology, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
  • 14Department of Neurology, Kyung Hee University College of Medicine, Seoul, Korea.
  • 15Department of Neurology, CHA University College of Medicine, Seongnam, Korea.
  • 16Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea.
  • 17Department of Neurology, Seoul National University Boramae Hospital, Seoul, Korea.
  • 18Department of Neurology, College of Medicine, Chungbuk National University, Chungbuk National University Hospital, Daejeon, Korea.
  • 19Department of Neurology, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea.
  • 20Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 21Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 22Department of Neurology, Kosin University College of Medicine, Busan, Korea.
  • 23Department of Neurology, College of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Korea.
  • 24Department of Neurology, Gyeongsang National University School of Medicine, Busan, Korea.
  • 25Department of Neurology, Konkuk University School of Medicine, Daejeon, Korea.
  • 26Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea.
  • 27Department of Neurology, Jeju National University Hospital, Jeju, Korea.
  • 28Department of Neurology, Konyang University Hospital, Daejeon, Korea.
  • 29Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, Korea.
  • 30Department of Neurology, School of Medicine, Kyungpook National Univeristy, Daegu, Korea.
  • 31Department of Neurology, College of Medicine, Soonchunhyang University, Cheonan, Korea.
  • 32Department of Neurology, College of Medicine, The Catholic University of Korea, Incheon, Korea.
  • 33Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
  • 34Department of Neurology, Dong-A University Medical Centre, Busan, Korea. jwkim@dau.ac.kr

Abstract

BACKGROUND AND PURPOSE
Nonmotor symptoms (NMS) in Parkinson's disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients.
METHODS
We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for assessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms.
RESULTS
In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage.
CONCLUSIONS
The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather exert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strategies is warranted to improve the HrQoL in PD patients.

Keyword

Parkinson's disease; non-motor symptoms; quality of life

MeSH Terms

Cognition
Demography
Humans
Korea
Movement Disorders*
Parkinson Disease*
Prevalence
Quality of Life*

Figure

  • Fig. 1 Scores of domain (or items) of NMSS according to the subgroup of PD patients (de novo:early:advanced). CV: cardiovascular, GI: gastrointestinal, NMSS: non-motor symptom scale, PD: Parkinson's disease.

  • Fig. 2 Correlations between NMSS total score and PDQ39 SI (rS=0.329, p<0.001). NMSS: non-motor symptom scale, PDQ39: Parkinson's Disease Questionnaire-39, PDQ39 SI: PDQ39 summary index.


Cited by  2 articles

Non-Motor Symptom Burdens Are Not Associated with Iron Accumulation in Early Parkinson's Disease: a Quantitative Susceptibility Mapping Study
Chaewon Shin, Seon Lee, Jee-Young Lee, Jung Hyo Rhim, Sun-Won Park
J Korean Med Sci. 2018;33(13):.    doi: 10.3346/jkms.2018.33.e96.

Subtypes of Sleep Disturbance in Parkinson's Disease Based on the Cross-Culturally Validated Korean Version of Parkinson's Disease Sleep Scale-2
Hui-Jun Yang, Han-Joon Kim, Seong-Beom Koh, Joong-Seok Kim, Tae-Beom Ahn, Sang-Myung Cheon, Jin Whan Cho, Yoon-Joong Kim, Hyeo-Il Ma, Mee Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, In-Uk Song, Ji-Young Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeok Lee, Jee-Young Lee, Ji Seon Kim, Ji Young Yun, Hee Jin Kim, Jin Yong Hong, Mi-Jung Kim, Jinyoung Youn, Ji Sun Kim, Eung Seok Oh, Won Tae Yoon, Sooyeoun You, Kyum-Yil Kwon, Hyung-Eun Park, Su-Yun Lee, Younsoo Kim, Hee-Tae Kim, Sang Jin Kim
J Clin Neurol. 2020;16(1):66-74.    doi: 10.3988/jcn.2020.16.1.66.


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