Pediatr Gastroenterol Hepatol Nutr.  2015 Dec;18(4):217-223. 10.5223/pghn.2015.18.4.217.

Early Life Factors Influencing the Risk of Obesity

• Lifschitz

• KMID: 2383298
• DOI: http://doi.org/10.5223/pghn.2015.18.4.217

Abstract

The obesity epidemic is a worldwide problem. Factors predisposing to obesity include genetics, race, socioeconomic conditions, birth by cesarean section, and perinatal antibiotic use. High protein (HP) content in infant formulas has been identified as a potential culprit predisposing to rapid weight gain in the first few months of life and leading to later obesity. In a large multicountry study the effects of lower protein (LP) formula (1.77 and 2.2 g protein/100 kcal, before and after the 5th month, respectively) were compared to those of higher protein (2.9 and 4.4 g protein/100 kcal, respectively). Results indicated that at 24 months, the weight-for-length z score of infants in the LP formula group was 0.20 (0.06, 0.34) lower than that of the HP group and was similar to that of the breastfed reference group. The authors concluded that a HP content of infant formula is associated with higher weight in the first 2 years of life but has no effect on length. LP intake in infancy might diminish the later risk of overweight and obesity. At 6 years of age HP children had a significantly higher body mass index (by 0.51; 95% confidence interval [CI], 0.13-0.90; p=0.009) and a 2.43 (95% CI, 1.12-5.27; p=0.024) fold greater risk of becoming obese than those who received the LP. In conclusion, several factors may influence development of metabolic syndrome and obesity. Breastfeeding should always be encouraged. An overall reduction of protein intake in formula non breastfed infants seems to be an additional way to prevent obesity.

Keyword

Obesity; Infant formula; Low protein formula; Cesarean section

MeSH Terms

Body Mass Index
Breast Feeding
Cesarean Section
Child
Continental Population Groups
Female
Genetics
Humans
Infant
Infant Formula
Obesity*
Overweight
Parturition
Pregnancy
Weight Gain

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