Clin Psychopharmacol Neurosci.  2017 May;15(2):181-183. 10.9758/cpn.2017.15.2.181.

Dose Dependent Course of Hyperprolactinemic and Normoprolactinemic Galactorrhea Induced by Venlafaxine

  • 1Department of Psychiatry, AfÅŸin State Hospital, AfÅŸin, Turkey.
  • 2Department of Internal Medicine, AfÅŸin State Hospital, AfÅŸin, Turkey.
  • 3Department of Psychiatry, Selçuk University School of Medicine, Selçuk, Turkey.
  • 4Department of Psychiatry, KahramanmaraÅŸ Sütçüİmam University, KahramanmaraÅŸ, Turkey.


Venlafaxine is a serotonergic and noradrenergic reuptake inhibitor which is used for the treatment of depression. We report a case of galactorrhea in a patient with major depressive disorder after starting treatment with venlafaxine. In particular, we discuss the course of hyper and normoprolactinemic galactorrhea. We managed this side effect initially by dose reduction and further by switching to essitalopram. Physicians should be aware of endocrinologic side effects such as galactorrhea during the serotonin and noradrenaline reuptake inhibitor treatment.


Venlafaxine hydrochloride; Galactorrhea; Prolactin; Depression; Therapeutics; Management
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