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Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks

Bayoumi AB, Ikizgul O, Karaali CN, Bozkurt S, Konya D, Toktas ZO

Antidepressant drugs can be advantageous in treating psychiatric and non-psychiatric illnesses, including spinal disorders. However, spine surgeons remain unfamiliar with the advantages and disadvantages of the use of antidepressant drugs...
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Korean Guidelines for the Treatment of Panic Disorder 2018 : Initial and Maintenance Treatment Strategies for the Pharmacological Treatment of Panic Disorder

Kim MK, Lee JH, Gim M, Kim W, Moon E, Seo HJ, Koo BH, Yang JC, Lee KS, Lee SH, Kim CH, Yu BH, Suh HS

OBJECTIVE: The Korean Association of Anxiety Disorders developed Korean guidelines for treatment of panic disorder (PD) 2018. In this paper, we discussed the consensus among psychiatrists, regarding initial and maintenance...
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Korean Guidelines for the Pharmacological Treatment of Social Anxiety Disorder: Initial Treatment Strategies

Yoon H, Oh DJ, Suh HS, Lee KU, Lim SW, Lee JY, Yang JC, Lee JH, Ha J, Lee BH, Kang SG, Yoon HK, Moon J, Bae SM, Kwon Y, Kim HC, Oh KS

OBJECTIVE: The aim of the present study was to provide clinical consensus and evidence regarding initial treatment strategies for the pharmacological treatment of social anxiety disorder (SAD) in Korea. METHODS: We...
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The Effect of Antidepressants on Mesenchymal Stem Cell Differentiation

Kruk JS, Bermeo S, Skarratt K, Fuller SJ, Duque G

BACKGROUND: Use of antidepressant medications has been linked to detrimental impacts on bone mineral density and osteoporosis; however, the cellular basis behind these observations remains poorly understood. The effect does...
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Paroxetine versus Venlafaxine and Escitalopram in Korean Patients with Major Depressive Disorder: A Randomized, Rater-blinded, Six-week Study

Woo YS, McIntyre R, Kim JB, Lee MS, Kim JM, Yim HW, Jun TY

OBJECTIVE: The purpose of this study was to compare the efficacy and safety of escitalopram, paroxetine and venlafaxine in Korean patients with major depressive disorder (MDD). METHODS: A total of 449...
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Codeine Precipitating Serotonin Syndrome in a Patient in Therapy with Antidepressant and Triptan

Milano G, Natta WM, Bello A, Martelli A, Mattioli F

The serotonin syndrome is a serioius medical condition due due to an intensive stimulation of setonin receptors. It is a rare, but severe, consequence of interaction between serotomimetic agents. This...
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Dose Dependent Course of Hyperprolactinemic and Normoprolactinemic Galactorrhea Induced by Venlafaxine

Camkurt MA, Gülpamuk , Fındiklı E, Elve R

Venlafaxine is a serotonergic and noradrenergic reuptake inhibitor which is used for the treatment of depression. We report a case of galactorrhea in a patient with major depressive disorder after...
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Evaluation of Overactive Bladder in Male Antidepressant Users: A Prospective Study

Solmaz V, Albayrak S, Tekatas A, Aksoy D, Gençten Y, İnanır S, Erdemir F

PURPOSE: In this study, we investigated overactive bladder (OAB) functions in male patients who used antidepressant drugs (ADs) that were previously examined in female patients, based on conflicting data in...
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Association between ABCB1 Polymorphisms and Antidepressant Treatment Response in Taiwanese Major Depressive Patients

Chang HH, Chou CH, Yang YK, Lee IH, Chen PS

OBJECTIVE: The multidrug resistance 1 (ABCB1, MDR1) gene, encoding P-glycoprotein, is extensively distributed and expressed in various tissues, such as a blood-brain barrier transporter. P-glycoprotein plays an important role in...
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Effects of Persisting Emotional Impact from Child Abuse and Norepinephrine Transporter Genetic Variation on Antidepressant Efficacy in Major Depression: A Pilot Study

Singh AB, Bousman CA, Ng CH, Byron K, Berk M

OBJECTIVE: Previous studies suggest child abuse and serotonergic polymorphism influence depression susceptibility and anti-depressant efficacy. Polymorphisms of the norepinephrine transporter (NET) may also be involved. Research in the area is...
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Profiling of Proteins Regulated by Venlafaxine during Neural Differentiation of Human Cells

Doh MS, Han DM, Oh DH, Kim SH, Choi MR, Chai YG

OBJECTIVE: Antidepressants are known to positively influence several factors in patients with depressive disorders, resulting in increased neurogenesis and subsequent relief of depressive disorders. To study the effects of venlafaxine...
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Efficacy of Venlafaxine Hydrochloride Extended Release for the Treatment of Perimenopausal Depressive Women with Vasomotor Symptoms: Open-Label Observation Study

Kim MR, Lee JG, Baek JH, Kim YH

OBJECTIVE: During the transition to menopause, various symptoms including vasomotor symptoms and depressed mood lead to low quality of life. We investigated the effect of low-dose venlafaxine hydrochloride extended release...
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Korean Pharmacological Treatment Guideline for Child-Adolescent Depression: The Efficacy and Choice of Antidepressant

Song HR, Lee YH, Yang S, Lee JY, Jang JW, Jeong S, Jeong H, Jo SJ, Yim HW, Lee SY, Jun TY

OBJECTIVE: The purpose of this guideline was to suggest recommendations for appropriate use of antidepressants in the child-adolescent depression. The differences of efficacy among antidepressants were evaluated. METHODS: Four kinds of...
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A Case of Venlafaxine-Induced Interstitial Lung Disease

Oh S, Cha SI, Kim H, Kim M, Choi SH, Seo H, Park TI

A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed...
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Medical Management for Intractable Pain Arising From Primary Sjogren Syndrome Involving Both Brain and Spinal Cord: A Case Report

Lee KM, Han KY, Kwon OP

Primary Sjogren syndrome, which involves lesions in both the brain and spinal cord, is rarely reported. Related symptoms, such as intractable pain due to central nervous system involvement, are very...
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Development of a LC-MS/MS for Quantification of Venlafaxine in Human Plasma and Application to Bioequivalence Study in healthy Korean Subjects

Kang HK, Kang MA, Kim HJ, Park YS, Kim SH, Kang JS

  • KMID: 2317857
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):35-42.
A simple, rapid and selective liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is developed and validated for quantification of venlafaxine in human plasma with simple liquid-liquid extraction step consisted...
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Agomelatine: The Novel Antidepressant

Woo YS, Wang HR, Bahk WM

  • KMID: 2287863
  • Korean J Psychopharmacol.
  • 2014 Jan;25(1):1-10.
Major depression is a common mental illness, associated with high morbidity and mortality. Antidepressants have been the first-line therapies due to their confirmed efficacy, however, considering high rate of poor...
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Venlafaxine-Induced Acute Toxic Hepatitis

Na KS, Hwang H, Kim SG, Lee SI, Jung HY

  • KMID: 2250138
  • Korean J Biol Psychiatry.
  • 2011 Aug;18(3):159-162.
Venlafaxine is among the most widely prescribed antidepressants. It is extensively metabolized to O-desmethylvenlafaxine via cytochrome P450 (CYP) 2D6. We report a case of acute toxic hepatitis resulting from venlafaxine...
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SSRIs and SNRIs for Management of Hot Flushing

Song JY, Kim MR, Kim JH

  • KMID: 2201111
  • J Korean Soc Menopause.
  • 2011 Aug;17(2):68-74.
For postmenopausal women who fear hormone therapy, women 60 years of age with continuous, severe hot flushing or women with a history of breast cancer, we should consider selective serotonin...
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Excessive Daytime Sleepiness Case Confounding with Thyrotoxicosis

Chung JK, Kim EJ

  • KMID: 2317504
  • Sleep Med Psychophysiol.
  • 2011 Jun;18(1):40-44.
Narcolepsy is a sleep disorder, which is characterized by excessive daytime sleepiness (EDS) that is typically associated with cataplexy, sleep fragmentation and other REM sleep-related phenomenon such as sleep paralysis...
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