J Korean Gastric Cancer Assoc.  2006 Sep;6(3):189-192.

A Case of Gastric Cancer Presenting Acute Disseminated Intravascular Coagulation Palliated with Combination Chemotherapy of Irinotecan and Cisplatin

Affiliations
  • 1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. insookwoo@catholic.ac.kr

Abstract

Acute disseminated intravascular coagulation (DIC) associated with gastric cancer is not common and has short survival of 1 to 3 weeks. Systemic chemotherapy in spite of hematologic unstability for gastric cancer may prolong survival time. A 47-year-old woman who complained of dyspnea, vaginal bleeding and easy bruisibility was diagnosed to stage IV gastric cancer with acute disseminated intravascular coagulation based on the laboratory data. She also had multiple bone metastases and bone marrow involvement. This is the first case treated with combination chemotherapy of irinotecan and cisplatin for advanced gastric cancer complicated by disseminated intravascular coagulation at the time of diagnosis. With systemic chemotherapy, some of the bleeding symptoms and the DIC process improved, even not completely recovered. However the patient died of disease progression and survival time was 12 weeks.

Keyword

Gastric cancer; Irinotecan; Disseminated intravascular coagulation

MeSH Terms

Bone Marrow
Cisplatin*
Dacarbazine
Diagnosis
Disease Progression
Disseminated Intravascular Coagulation*
Drug Therapy
Drug Therapy, Combination*
Dyspnea
Female
Hemorrhage
Humans
Middle Aged
Neoplasm Metastasis
Stomach Neoplasms*
Uterine Hemorrhage
Cisplatin
Dacarbazine
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