Korean J Dermatol.  2017 Jan;55(1):20-26.

Recent Trends in Methicillin-resistant Staphylococcus aureus Infection and Antibiotic Treatment in Staphylococcal Scalded Skin Syndrome in Patients in Childhood: A Single-center Study

Affiliations
  • 1Department of Dermatology, School of Medicine, Keimyung University, Daegu, Korea. skksasf@hanmail.net

Abstract

BACKGROUND
Staphylococcal scalded skin syndrome (SSSS) is a blistering disease of superficial skin mediated by Staphylococcus aureus (S. aureus) exfoliative toxin. Generally, SSSS affects mainly infants and children younger than 5 years and has a good prognosis. However, an increasing number of cases of methicillin-resistant S. aureus (MRSA) have been reported recently.
OBJECTIVE
The purposes of this study were to evaluate the clinical features and course, to investigate the microbiological manifestations, and to perform antimicrobial susceptibility testing of SSSS among Korean children.
METHODS
From March 2003 to July 2016, a total of 141 children were included in this study. The patients were divided into two different groups according to time of onset of their disease: before or after September 2011. We retrospectively reviewed medical records, microbiological results, bacterial detection sites, and antimicrobial susceptibility tests of all participating children. The results of comparison between the two groups were evaluated using the chi-square test.
RESULTS
S. aureus infections were identified in all patients. Among all cultured S. aureus specimens, 63.1% (89/141) showed methicillin resistance. Beginning in September 2011, MRSA infection showed a significantly higher prevalence than that previously demonstrated (71.7% vs. 38.8%; p=0.0010). Moreover, MRSA infections were detected on the skin and neck and in the nose (each detected on 61, 41, and 18 occasions, respectively) with overlap observed in many cases.
CONCLUSION
In conclusion, since the prevalence of MRSA infection has been gradually increasing in recent years, careful consideration is needed in the selection of antibiotics covering MRSA.

Keyword

Antimicrobial susceptibility test; Methicillin-resistant Staphylococcus aureus; Staphylococcal scalded skin syndrome

MeSH Terms

Anti-Bacterial Agents
Blister
Child
Humans
Infant
Medical Records
Methicillin Resistance*
Methicillin-Resistant Staphylococcus aureus*
Neck
Nose
Prevalence
Prognosis
Retrospective Studies
Skin
Staphylococcal Scalded Skin Syndrome*
Staphylococcus aureus
Anti-Bacterial Agents
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