Kosin Med J.  2018 Jun;33(1):12-19. 10.7180/kmj.2018.33.1.12.

Antibiotic resistance of Staphylococcus aureus colonized in children with staphylococcal scalded skin syndrome

• Kong SG

• KMID: 2415836
• DOI: http://doi.org/10.7180/kmj.2018.33.1.12

Abstract

OBJECTIVES
Systemic antibiotic therapy with semisynthetic penicillinase-resistant penicillin or vancomycin and clindamycin are recommended for the treatment of staphylococcal scalded skin syndrome (SSSS). This study assessed the rate of antibiotic resistance of Staphylococcus aureus isolated from the anterior nares or skin of children diagnosed with SSSS.
METHODS
A retrospective review of the medical records of 25 patients with SSSS between July 2010 and October 2014 was conducted. The clinical characteristics of patients were collected and the antibiotic susceptibility of S. aureus were analyzed using automated systems.
RESULTS
The median age of the patients was 22 months (range: 2-95). Ninety-two percent of patients were less than 5 years of age. Nasal swab samples of all patients and skin swab samples of 17 patients were cultured to isolate S. aureus. Twenty-one (84%) of 25 patients were colonized with methicillin-resistant S. aureus (MRSA). The results of swab samples of the other four patients were no growth or isolation of bacteria other than S. aureus. Among 20 strains isolated from the anterior nares, 1 strain (5%) was methicillin-susceptible S. aureus. All 15 strains isolated from the skin were MRSA. All 21 strains isolated from anterior nares or skin were found to be resistant to clindamycin upon evaluation using automated systems.
CONCLUSIONS
The rates of methicillin and clindamycin resistance in S. aureus colonized in children with SSSS were very high. Further studies evaluating proper antibiotic regimens and the effectiveness of systemic antibiotic therapy are needed.

Keyword

Bacterial; Child; Colonization; Drug resistance; Staphylococcal scalded skin syndrome

MeSH Terms

Bacteria
Child*
Clindamycin
Colon*
Drug Resistance
Drug Resistance, Microbial*
Humans
Medical Records
Methicillin
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Penicillins
Retrospective Studies
Skin
Staphylococcal Scalded Skin Syndrome*
Staphylococcus aureus*
Staphylococcus*
Vancomycin
Clindamycin
Methicillin
Penicillins
Vancomycin

Figure

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  Fig. 1. Monthly distribution of staphylococcal scalded skin syndrome.

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