Psychiatry Investig.  2017 Jan;14(1):100-106. 10.4306/pi.2017.14.1.100.

Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

Affiliations
  • 1Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea. leehjeong@korea.ac.kr
  • 2Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • 3Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • 4Department of Psychiatry, Seoul National University Bundang Hospital, College of Medicine, Seongnam, Republic of Korea.
  • 5Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • 6Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, Republic of Korea.
  • 7Department of Psychiatry, Pusan National University School of Medicine, Busan, Republic of Korea.
  • 8Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea.
  • 9Department of Psychiatry, Chonnam National University College of Medicine, Gwangju, Republic of Korea.
  • 10Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea.

Abstract

The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2) in South Korea. The study subjects consist of two populations: 1) patients with mood disorders under 25 years old and 2) patients with mood disorders within 2 years of treatment under 35 years old. After successful screening, the subjects are evaluated using baseline assessments and serial follow-up assessments at 3-month intervals. Between the follow-up assessments, subjects are dictated to check their own daily mood status before bedtime using the eMood chart application or a paper mood diary. At the regular visits every 3 months, inter-visit assessments are evaluated based on daily mood charts and interviews with patients. In addition to the daily mood chart, sleep quality, inter-visit major and minor mood episodes, stressful life events, and medical usage pattern with medical expenses are also assessed. Genomic DNA from blood is obtained for genomic analyses. From the MDCRC study, the clinical course, prognosis, and related factors of early-onset mood disorders can be clarified. The MDCRC is also able to facilitate translational research for mood disorders and provide a resource for the convergence study of mood disorders.

Keyword

Cohort study; Early mood disorders; Bipolar disorder; Major depressive disorder; MDCRC
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