J Vet Sci.  2016 Mar;17(1):97-102. 10.4142/jvs.2016.17.1.97.

Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats

Affiliations
  • 1Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea. hykim@konkuk.ac.kr
  • 2Department of Veterinary Surgery, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea.
  • 3Seoul Cord Blood Bank, Histostem Co, Seoul 05372, Korea.
  • 4Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
  • 5Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.

Abstract

We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extract from entire injured spinal cord showed increased expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Our results show that treatment of SCI with hUCB-MSCs can improve locomotor functions, and suggest that increased levels of BDNF, NGF and NT-3 in the injured spinal cord were the main therapeutic effect.

Keyword

brain-derived neurotrophic factor; nerve growth factor; neurotrophic factor; neurotrophin-3; spinal cord injury
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