J Vet Sci.  2016 Mar;17(1):53-61. 10.4142/jvs.2016.17.1.53.

Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats

  • 1Military Medical Center "Karaburma", 11000 Belgrade, Serbia. bracadejanovic@yahoo.com
  • 2Institute for Medical Research, Military Medical Academy, 11000 Belgrade, Serbia.
  • 3Institute for Biochemistry, Faculty of Medicine, University of Nis, 18000 Nis, Serbia.
  • 4Institute for Biological Research "Sinisa Stankovic", University of Belgrade, 11000 Belgrade, Serbia.
  • 5Institute of Meat Hygiene and Technology, 11000 Belgrade, Serbia.
  • 6Department of Obstetrics, Faculty of Veterinary Medicine, 11000 Belgrade, Serbia.


This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ and AGM (75 mg/kg BW). The control group was treated with 0.9% saline solution in the same manner. All tested compounds were administered i.p. in a single dose. Rats were sacrificed by decapitation 48 h after treatment Treatment with AGM significantly attenuated the oxidative stress parameters and restored antioxidant capacity in the forebrain cortex. The data indicated that i.p. administered AGM exerted antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes and microglia may contribute to secondary nerve-cell damage and participate in the balance of destructive vs. protective actions involved in the pathogenesis after poisoning.


agmatine; antioxidant defense; astrocytes; chlorpromazine; oxidative stress
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