Tissue Eng Regen Med.  2016 Apr;13(2):155-161. 10.1007/s13770-016-9085-2.

Substance P Modulates Properties of Normal and Diabetic Dermal Fibroblasts

  • 1Graduate School of Biotechnology & Department of Genetic Engineering, Kyung Hee University, Yongin, Korea.
  • 2East-West Medical Research Institute & College of Medicine, Kyung Hee University, Seoul, Korea. kisookpark@khu.ac.kr


Dermal fibroblasts play essential roles in wound healing. However, they lose their normal regenerative functions under certain pathologic conditions such as in chronic diabetic wounds. Here, we show that substance P (SP) rescues the malfunctions of dermal fibroblasts in diabetes. SP increased the proliferation of diabetic dermal fibroblasts dose-dependently, although the effect was lower compared to the SP-stimulated proliferation of normal dermal fibroblasts. In contrast to normal dermal fibroblasts, SP increased the expression level of vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1 (SDF-1) in diabetic dermal fibroblast hence, rescuing their angiogenic potential. The cellular characteristics of diabetic dermal fibroblasts modulated by SP would be able to accelerate the wound healing process through faster wound contraction and improved angiogenesis in diabetic chronic wounds. Moreover, SP pretreatment into dermal fibroblasts isolated from diabetic patients would be a promising strategy to develop autologous cell therapy for treating diabetic chronic wounds.


Vascular endothelial growth factor; Stromal cell-derived factor-1

MeSH Terms

Cell- and Tissue-Based Therapy
Substance P*
Vascular Endothelial Growth Factor A
Wound Healing
Wounds and Injuries
Substance P
Vascular Endothelial Growth Factor A
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