- Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
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Lin S, Yu L, Ni Y, He L, Weng X, Lu X, Zhang C
- KMID: 2470964
- Diabetes Metab J.
- 2020 Feb;44(1):158-172.
- doi: 10.4093/dmj.2018.0235
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated... -
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- Plasma Fibroblast Growth Factor 23 Concentration Is Associated with Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients
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Chang Y, Kim J, Woo HG, Ryu DR, Oh HJ, Song TJ
- KMID: 2467781
- J Clin Neurol.
- 2020 Jan;16(1):29-36.
- doi: 10.3988/jcn.2020.16.1.29
BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is associated with atherosclerosis via nitric-oxide-associated endothelial dysfunction and calcium-phosphate-related bone mineralization. This study aimed to determine the association of the plasma... -
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- Follistatin Mitigates Myofibroblast Differentiation and Collagen Synthesis of Fibroblasts from Scar Tissue around Injured Flexor Tendons
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Kang YM, Lee SK, Chun YM, Choi YR, Moon SH, Lee HM, Kang HJ
- KMID: 2466340
- Yonsei Med J.
- 2020 Jan;61(1):85-93.
- doi: 10.3349/ymj.2020.61.1.85
PURPOSE: The aim of this study was to investigate the effect of FST gene on the inhibition of fibrosis in fibroblastic cells from scar tissue around repaired zone II flexor... -
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- Chemical Regeneration of Wound Defects: Relevance to the Canine Palatal Mucosa and Cell Cycle Up-Regulation in Human Gingival Fibroblasts
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Lee K, Ben Amara , Lee SC, Leesungbok R, Chung MA, Koo KT, Lee SW
- KMID: 2467059
- Tissue Eng Regen Med.
- 2019 Dec;16(6):675-684.
- doi: 10.1007/s13770-019-00227-6
BACKGROUND: Trichloroacetic acid (TCA) is an agent widely applied in dermatology for skin regeneration. To test whether TCA can offer an advantage for the regeneration of oral soft tissue defects,... -
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- Direct Reprogramming to Human Induced Neuronal Progenitors from Fibroblasts of Familial and Sporadic Parkinson’s Disease Patients
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Lee M, Sim H, Ahn H, Ha J, Baek A, Jeon YJ, Son MY, Kim J
- KMID: 2465888
- Int J Stem Cells.
- 2019 Nov;12(3):474-483.
- doi: 10.15283/ijsc19075
In Parkinson’s disease (PD) research, human neuroblastoma and immortalized neural cell lines have been widely used as in vitro models. The advancement in the field of reprogramming technology has provided... -
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- Role of Hydrogen Sulfide in the Survival of Fibroblasts and Fibroblast-mediated Contraction of Collagen Gel
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Park HJ, Kim JW
- KMID: 2460516
- J Korean Ophthalmol Soc.
- 2019 Oct;60(10):975-981.
- doi: 10.3341/jkos.2019.60.10.975
PURPOSE: To investigate the role of hydrogen sulfide in the survival and collagen gel contraction of cultured human Tenon's capsule fibroblasts (HTCFs). METHODS: Primarily cultured HTCFs were exposed to 0, 100,... -
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- The Effect of Trigonella foenum-graceum L. (Fenugreek) Towards Collagen Type I Alpha 1 (COL1A1) and Collagen Type III Alpha 1 (COL3A1) on Postmenopausal Woman's Fibroblast
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Yusharyahya SN, Bramono K, Sutanto NR, Kusuma I
- KMID: 2459961
- Nat Prod Sci.
- 2019 Sep;25(3):208-214.
- doi: 10.20307/nps.2019.25.3.208
Trigonella foenum-graceum L. (fenugreek) is a phytoestrogen, a nonsteroidal organic chemical compound from plants which has similar mechanism of action to sex hormone estradiol-17β. This study aims to assess the... -
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- Radiographic manifestations of fibroblastic osteosarcoma: A diagnostic challenge
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Tahmasbi-Arashlow M, Barnts KL, Nair MK, Cheng YS, Reddy LV
- KMID: 2458373
- Imaging Sci Dent.
- 2019 Sep;49(3):235-240.
- doi: 10.5624/isd.2019.49.3.235
Osteosarcoma is the most common primary bone tumor after plasma cell neoplasms. Osteosarcoma has diverse histological features and is characterized by the presence of malignant spindle cells and pluripotent neoplastic... -
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- Helicobacter pylori inhibited cell proliferation in human periodontal ligament fibroblasts through the Cdc25C/CDK1/cyclinB1 signaling cascade
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Li H, Liang D, Hu N, Dai X, He J, Zhuang H, Zhao W
- KMID: 2454084
- J Periodontal Implant Sci.
- 2019 Jun;49(3):138-147.
- doi: 10.5051/jpis.2019.49.3.138
PURPOSE: Several studies have shown that the oral cavity is a secondary location for Helicobacter pylori colonization and that H. pylori is associated with the severity of periodontitis. This study... -
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- Effect of Manuka Honey on Transforming Growth Factor Beta-1-Induced Extracelluar Matrix Production in Nasal Polyp Derived Fibroblasts
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Kil BK, Kim BM, Kang BJ, Ye MK, Shin SH
- KMID: 2451614
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Jun;62(6):336-342.
- doi: 10.3342/kjorl-hns.2018.00682
BACKGROUND AND OBJECTIVES: Manuka honey has anti-microbial, anti-inflammatory, and anti-proliferative action with a high concentration of methylglyoxal compound. It is also effective in killing Staphylococcus aureus biofilm and effective for... -
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- MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts
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Zhang C, Dai J, Fan Y, He X, Wei R
- KMID: 2448356
- Korean J Intern Med.
- 2019 May;34(3):634-642.
- doi: 10.3904/kjim.2016.315
BACKGROUND/AIMS: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts. METHODS: Primary human dermal fibroblasts were separated from normal human skin samples.... -
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- Cancer-Associated Fibroblasts and Desmoplastic Reactions Related to Cancer Invasiveness in Patients With Colorectal Cancer
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Shin N, Son GM, Shin DH, Kwon MS, Park BS, Kim HS, Ryu D, Kang CD
- KMID: 2446792
- Ann Coloproctol.
- 2019 Feb;35(1):36-46.
- doi: 10.3393/ac.2018.09.10
PURPOSE: We evaluated the relationship of cancer-associated fibroblasts (CAFs) and desmoplastic reactions with cancer invasiveness and long-term outcomes in patients with colorectal cancer (CRC). METHODS: Histologic evaluation of mature CAFs and... -
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- Gene Expression in Cultured Keloid Fibroblasts
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Kim DH, Kim UK, Choi KH, Park K
- KMID: 2440723
- Korean J Dermatol.
- 2019 Feb;57(2):59-65.
BACKGROUND: Keloids are the result of an overgrowth of dense fibrous tissue. The mechanisms involved in keloid formation remain unknown. OBJECTIVE: To understand the mechanism of keloid formation, differences in gene... -
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- Poly-L-Lactic Acid Increases Collagen Gene Expression and Synthesis in Cultured Dermal Fibroblast (Hs68) Through the p38 MAPK Pathway
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Kim SA, Kim HS, Jung JW, Suh SI, Ryoo YW
- KMID: 2430812
- Ann Dermatol.
- 2019 Feb;31(1):97-100.
- doi: 10.5021/ad.2019.31.1.97
No abstract available. -
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- Effect of bFGF and fibroblasts combined with hyaluronic acid-based hydrogels on soft tissue augmentation: an experimental study in rats
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Lee SY, Park Y, Hwang SJ
- KMID: 2468994
- Maxillofac Plast Reconstr Surg.
- 2019 ;41(1):47.
- doi: 10.1186/s40902-019-0234-0
BACKGROUND: Hyaluronic acid (HA) has been applied as a primary biomaterial for temporary soft tissue augmentation and as a carrier for cells and the delivery of growth factors to promote... -
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- Cancer-Associated Fibroblasts Promote the Chemo-resistance in Gastric Cancer through Secreting IL-11 Targeting JAK/STAT3/Bcl2 Pathway
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Ma J, Song X, Xu X, Mou Y
- KMID: 2437613
- Cancer Res Treat.
- 2019 Jan;51(1):194-210.
- doi: 10.4143/crt.2018.031
PURPOSE: Our aim was to detect the potential role of interleukin 11 (IL-11) in the development of chemo-resistance in gastric cancer and to reveal the mechanism involved in the process. MATERIALS... -
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- Keratinocyte Migration in a Three-Dimensional In Vitro Wound Healing Model Co-Cultured with Fibroblasts
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Iyer K, Chen Z, Ganapa T, Wu BM, Tawil B, Linsley CS
- KMID: 2441264
- Tissue Eng Regen Med.
- 2018 Dec;15(6):721-733.
- doi: 10.1007/s13770-018-0145-7
BACKGROUND: Because three-dimensional (3D) models more closely mimic native tissues, one of the goals of 3D in vitro tissue models is to aid in the development and toxicity screening of... -
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- Mbd3 Promotes Reprogramming of Primary Human Fibroblasts
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Jaffer S, Goh P, Abbasian M, Nathwani A
- KMID: 2429556
- Int J Stem Cells.
- 2018 Nov;11(2):235-241.
- doi: 10.15283/ijsc18036
Mbd3 (Methyl-CpG binding domain protein), a core member of NuRD (nucleosome remodelling and deacetylation) is essential for embryogenesis. However, its role in reprogramming of somatic cells into induced pluripotent stem... -
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- Effects of Valproic Acid on the Survival of Human Tennon's Capsule Fibroblasts
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Lee SE, Kim JW
- KMID: 2426367
- J Korean Ophthalmol Soc.
- 2018 Nov;59(11):1056-1061.
- doi: 10.3341/jkos.2018.59.11.1056
PURPOSE: To investigate the effects of valproic acid on the survival of cultured human Tenon's capsule fibroblasts (HTFBs). METHODS: Primary cultured HTFBs were exposed to 0, 0.25, 0.5, and 1.0 mM... -
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- The Effect of Fibronectin-Immobilized Microgrooved Titanium Substrata on Cell Proliferation and Expression of Genes and Proteins in Human Gingival Fibroblasts
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Kim EC, Lee DY, Lee MH, Lee HJ, Kim KH, Leesungbok R, Ahn SJ, Park SJ, Yoon JH, Jee YJ, Lee SC, Lee SW
- KMID: 2422675
- Tissue Eng Regen Med.
- 2018 Oct;15(5):615-627.
- doi: 10.1007/s13770-018-0153-7
BACKGROUND: We aimed to determine the effect of fibronectin (FN)-immobilized microgrooved titanium (Ti) on human gingival fibroblast proliferation, gene expression and protein expression. METHODS: Photolithography was used to fabricate the microgrooved... -
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