Korean J Parasitol.  2015 Dec;53(6):699-703. 10.3347/kjp.2015.53.6.699.

Prevalence of Serum IgG Antibodies to Cystic Echinococcus Antigen among Patients in an Uzbekistan Emergency Hospital

• Park SJ
• Han SS
• Anvarov K
• Khajibaev
• Choi MH
• Hong ST

• KMID: 2360150
• DOI: http://doi.org/10.3347/kjp.2015.53.6.699

Abstract

Cystic echinococcosis (CE) is one of the most widespread zoonotic helminthiases, which can last an asymptomatic infection for several years. The purpose of this study was to demonstrate serum antibody prevalence of CE among asymptomatic people in Uzbekistan using ELISA. A total of 2,547 serum samples were collected, 66 from confirmed CE patients and 2,481 of patients with other diseases than CE at a hospital in Tashkent, Uzbekistan. The serum samples were screened for CE specific IgG antibodies by ELISA using cystic fluid antigen obtained from sheep. The serum antibody positive rate was 89.4% (59/66) in CE and 3.6% (89/2,481) in other disease patients. The present ELISA recognized 89.4% sensitivity and 96.4% specificity. The ELISA absorbance of positive samples was distributed 0.271-0.971 for CE and 0.273-0.887 for other disease patients. The other disease patients with high absorbance over 0.3 were 50 (2.0%) who were presumed to be active CE patients. The patients in their 40s showed the highest positive rate of 5.2% (P=0.181), and women were 4.4% while men were 3.1% positive (P=0.136). The data confirmed that there are many asymptomatic patients of CE in Tashkent. It is indicated that CE is an endemic disease of public health importance in Uzbekistan.

Keyword

Echinococcus granulosus; cystic echinococcosis; serum antibody; ELISA; positive rate; asymptomatic patient; Uzbekistan

MeSH Terms

Adolescent
Adult
Aged
Aged, 80 and over
Animals
Antibodies, Helminth/*blood
Child
Child, Preschool
Echinococcosis/*blood/epidemiology/parasitology
Echinococcus/*immunology/isolation & purification
Emergency Service, Hospital
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G/*blood
Male
Middle Aged
Prevalence
Uzbekistan/epidemiology
Young Adult
Antibodies, Helminth
Immunoglobulin G