J Korean Ophthalmol Soc.  2016 Oct;57(10):1598-1603. 10.3341/jkos.2016.57.10.1598.

The Effect of Fluorescein Angiography on Renal Function in Patients with Diabetic Retinopathy

• Kim JT
• Jin SY
• Chang YS
• Hwang WM
• Lee YH

• KMID: 2355416
• DOI: http://doi.org/10.3341/jkos.2016.57.10.1598

Abstract

PURPOSE
This study was designed to compare the change of renal function before and after fluorescein angiography in patients with diabetic retinopathy.
METHODS
This study included 80 patients diagnosed with diabetic retinopathy who did not receive dialysis from April 2004 to December 2014. Based on retrospective analysis of a blood test performed within one week before and after fluorescein angiography, the changes of blood urea nitrogen (BUN), serum creatinine (Scr), and estimated glomerular filtration rate (eGFR) were measured. Additionally, the effect of fluorescein angiography on renal function was estimated according to chronic kidney disease (CKD) stage.
RESULTS
The average BUN/SCr before and after fluorescein angiography was not statistically significantly different before and after fluorescein angiography. The average eGFR before and after fluorescein angiography increased from 62.62 ± 31.59 to 66.46 ± 31.22 (p = 0.006). Regarding changes in renal functions according to CKD stage, based on the average eGFR in CKD stages 5, 4, 2, and 1, no significant differences were observed in renal functions before and after fluorescein angiography, whereas eGFR was significantly increased after fluorescein angiography at CKD stage 3 (p = 0.042).
CONCLUSIONS
In patients with diabetic retinopathy, BUN/Scr and eGFR were not significantly different before or after fluorescein angiography. Moreover, the deterioration of renal function was not observed at any CKD stage. Therefore, fluorescein angiography is a relatively safe diagnostic examination in patients with diabetic retinopathy who did not receive dialysis due to the low-risk of renal function deterioration.

Keyword

Fluorescein angiography; Renal function

MeSH Terms

Blood Urea Nitrogen
Creatinine
Diabetic Retinopathy*
Dialysis
Fluorescein Angiography*
Fluorescein*
Glomerular Filtration Rate
Hematologic Tests
Humans
Renal Insufficiency, Chronic
Retrospective Studies
Creatinine
Fluorescein

Reference

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