J Korean Neuropsychiatr Assoc.  2012 Nov;51(6):387-394.

Clinical Characteristics and Use of Antidepressants among Cancer Patients Referred for Psychiatric Consultation : A Korean Multicenter Survey

Affiliations
  • 1Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. Ks2485@empal.com
  • 2Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
  • 3Department of Psychiatry, School of Medicine, Konkuk University, Seoul, Korea.
  • 4Department of Psychiatry, School of Medicine, Kyung Hee University, Seoul, Korea.
  • 5Department of Psychiatry, Hallym University College of Medicine, Seoul, Korea.
  • 6Department of Psychiatry, Dong-A University College of Medicine, Busan, Korea.
  • 7Department of Psychiatry, Ilsanpaik Hospital, Inje University College of Medicine, Goyang, Korea.
  • 8Department of Psychiatry, Chonnam National University Medical School, Hwasun, Korea.
  • 9Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Korea.
  • 10Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.

Abstract


OBJECTIVES
Antidepressants are frequently used for treatment of psychological distress among cancer patients. The aim of this study is to investigate the characteristics of psychiatric consultations and antidepressant use for cancer patients.
METHODS
Participants in the study included cancer patients who had been referred for psychiatric consultation. A total of 488 patients were recruited from nine general hospitals in Korea. Questionnaires based on medical records, including antidepressants prescribed, were investigated by psychiatrists.
RESULTS
The most common psychiatric diagnosis of subjects was depressive disorders (72.4%), followed by anxiety disorders (13.0%), and adjustment disorders (7.3%). Antidepressants were prescribed for 96.3% of subjects and escitalopram, mirtazapine, and paroxetine were prescribed frequently, in order. Anxiolytics and hypnotics were used for 58.2% of the subjects, for which lorazepam and alprozolam were preferred. During the study period, 226 (46.8%) subjects discontinued treatment and the most common cause was improvement of symptoms (123, 54.4%).
CONCLUSION
Our results showed a tendency of prescription of antidepressants and anxiolytics and common psychiatric problems in Korean cancer patients. We suppose that these data would be helpful to clinicians who manage psychiatric symptoms of cancer patients.

Keyword

Cancer; Antidepressant; Prescription pattern; Psychiatric consultation

MeSH Terms

Adjustment Disorders
Anti-Anxiety Agents
Antidepressive Agents
Anxiety Disorders
Citalopram
Depressive Disorder
Hospitals, General
Humans
Hypnotics and Sedatives
Korea
Lorazepam
Medical Records
Mental Disorders
Mianserin
Paroxetine
Prescriptions
Surveys and Questionnaires
Referral and Consultation
Anti-Anxiety Agents
Antidepressive Agents
Citalopram
Hypnotics and Sedatives
Lorazepam
Mianserin
Paroxetine

Reference

1. Statistics Korea. Annual Report on the Cause of Death Statistics. 2010. Daejeon: Statistics Korea.
Article
2. Derogatis LR, Morrow GR, Fetting J, Penman D, Piasetsky S, Schmale AM, et al. The prevalence of psychiatric disorders among cancer patients. JAMA. 1983. 249:751–757.
Article
3. Massie MJ. Prevalence of depression in patients with cancer. J Natl Cancer Inst Monogr. 2004. 57–71.
Article
4. Castelli L, Binaschi L, Caldera P, Torta R. Depression in lung cancer patients: is the HADS an effective screening tool? Support Care Cancer. 2009. 17:1129–1132.
Article
5. Holland JC. Anxiety and cancer: the patient and the family. J Clin Psychiatry. 1989. 50:Suppl. 20–25.
Article
6. Andrykowski MA, Jacobsen PB, Marks E, Gorfinkle K, Hakes TB, Kaufman RJ, et al. Prevalence, predictors, and course of anticipatory nausea in women receiving adjuvant chemotherapy for breast cancer. Cancer. 1988. 62:2607–2613.
Article
7. Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L, Johansen C, et al. Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol. 2011. 12:160–174.
Article
8. Massie MJ, Holland JC. Diagnosis and treatment of depression in the cancer patient. J Clin Psychiatry. 1984. 45(3 Pt 2):25–29.
Article
9. Filiberti A, Ripamonti C. Suicide and suicidal thoughts in cancer patients. Tumori. 2002. 88:193–199.
Article
10. Ashbury FD, Madlensky L, Raich P, Thompson M, Whitney G, Hotz K, et al. Antidepressant prescribing in community cancer care. Support Care Cancer. 2003. 11:278–285.
11. Kissane DW, Grabsch B, Love A, Clarke DM, Bloch S, Smith GC. Psychiatric disorder in women with early stage and advanced breast cancer: a comparative analysis. Aust N Z J Psychiatry. 2004. 38:320–326.
12. Colleoni M, Mandala M, Peruzzotti G, Robertson C, Bredart A, Goldhirsch A. Depression and degree of acceptance of adjuvant cytotoxic drugs. Lancet. 2000. 356:1326–1327.
Article
13. Lloyd-Williams M, Shiels C, Taylor F, Dennis M. Depression--an independent predictor of early death in patients with advanced cancer. J Affect Disord. 2009. 113:127–132.
Article
14. Lansky SB, List MA, Herrmann CA, Ets-Hokin EG, DasGupta TK, Wilbanks GD, et al. Absence of major depressive disorder in female cancer patients. J Clin Oncol. 1985. 3:1553–1560.
Article
15. Bellini M, Capannini D. [Increased suicide risk in cancer patients]. Minerva Psichiatr. 1994. 35:175–186.
Article
16. Reiche EM, Nunes SO, Morimoto HK. Stress, depression, the immune system, and cancer. Lancet Oncol. 2004. 5:617–625.
Article
17. Fisch MJ, Loehrer PJ, Kristeller J, Passik S, Jung SH, Shen J, et al. Fluoxetine versus placebo in advanced cancer outpatients: a double-blinded trial of the Hoosier Oncology Group. J Clin Oncol. 2003. 21:1937–1943.
Article
18. Morrow GR, Hickok JT, Roscoe JA, Raubertas RF, Andrews PL, Flynn PJ, et al. Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester Cancer Center Community Clinical Oncology Program. J Clin Oncol. 2003. 21:4635–4641.
Article
19. McGeeney BE. Adjuvant agents in cancer pain. Clin J Pain. 2008. 24:Suppl 10. S14–S20.
Article
20. Kim SW, Shin IS, Kim JM, Kim YC, Kim KS, Kim KM, et al. Effectiveness of mirtazapine for nausea and insomnia in cancer patients with depression. Psychiatry Clin Neurosci. 2008. 62:75–83.
Article
21. Triozzi PL, Goldstein D, Laszlo J. Contributions of benzodiazepines to cancer therapy. Cancer Invest. 1988. 6:103–111.
Article
22. Glass RM. Psychiatric disorders among cancer patients. JAMA. 1983. 249:782–783.
Article
23. Akechi T, Okuyama T, Sugawara Y, Nakano T, Shima Y, Uchitomi Y. Major depression, adjustment disorders, and post-traumatic stress disorder in terminally ill cancer patients: associated and predictive factors. J Clin Oncol. 2004. 22:1957–1965.
Article
24. Akechi T, Okamura H, Nakano T, Akizuki N, Okamura M, Shimizu K, et al. Gender differences in factors associated with suicidal ideation in major depression among cancer patients. Psychooncology. 2010. 19:384–389.
25. Sadock BJ, Sadock VA, Pipino LL. Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry. 2007. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins.
26. Gnanadesigan N, Espinoza RT, Smith R, Israel M, Reuben DB. Interaction of serotonergic antidepressants and opioid analgesics: is serotonin syndrome going undetected? J Am Med Dir Assoc. 2005. 6:265–269.
Article
27. Goetz MP, Knox SK, Suman VJ, Rae JM, Safgren SL, Ames MM, et al. The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat. 2007. 101:113–121.
Article
28. Koriech OM. Fluoxetine treatment comprises the antiemetic efficacy of ondansetron in cancer patients. Clin Oncol (R Coll Radiol). 1995. 7:371–372.
Article
29. Rao N. The clinical pharmacokinetics of escitalopram. Clin Pharmacokinet. 2007. 46:281–290.
Article
30. Brøsen K, Naranjo CA. Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram. Eur Neuropsychopharmacol. 2001. 11:275–283.
Article
31. Theobald DE, Kirsh KL, Holtsclaw E, Donaghy K, Passik SD. An open label pilot study of citalopram for depression and boredom in ambulatory cancer patients. Palliat Support Care. 2003. 1:71–77.
Article
32. Möslinger-Gehmayr R, Zaninelli R, Contu A, Oberhoff C, Gutschow K, Schindler AE, et al. [A double-blind comparative study of the effectiveness and tolerance of paroxetine and amitriptyline in treatment of breast cancer patients with clinically assessed depression]. Zentralbl Gynakol. 2000. 122:195–202.
Article
33. Bishop JF, Olver IN, Wolf MM, Matthews JP, Long M, Bingham J, et al. Lorazepam: a randomized, double-blind, crossover study of a new antiemetic in patients receiving cytotoxic chemotherapy and prochlorperazine. J Clin Oncol. 1984. 2:691–695.
Article
34. Kris MG, Gralla RJ, Clark RA, Tyson LB, Groshen S. Antiemetic control and prevention of side effects of anti-cancer therapy with lorazepam or diphenhydramine when used in combination with metoclopramide plus dexamethasone. A double-blind, randomized trial. Cancer. 1987. 60:2816–2822.
35. Razavi D, Delvaux N, Farvacques C, De Brier F, Van Heer C, Kaufman L, et al. Prevention of adjustment disorders and anticipatory nausea secondary to adjuvant chemotherapy: a double-blind, placebo-controlled study assessing the usefulness of alprazolam. J Clin Oncol. 1993. 11:1384–1390.
36. Holland JC, Morrow GR, Schmale A, Derogatis L, Stefanek M, Berenson S, et al. A randomized clinical trial of alprazolam versus progressive muscle relaxation in cancer patients with anxiety and depressive symptoms. J Clin Oncol. 1991. 9:1004–1011.
37. Cohn JB, Wilcox CS. Low-sedation potential of buspirone compared with alprazolam and lorazepam in the treatment of anxious patients: a double-blind study. J Clin Psychiatry. 1986. 47:409–412.
38. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 1994. 4th ed. Washington, DC: American Psychiatric Press.
Article
39. Kathol RG, Noyes R Jr, Williams J, Mutgi A, Carroll B, Perry P. Diagnosing depression in patients with medical illness. Psychosomatics. 1990. 31:434–440.
Article
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