J Korean Neuropsychiatr Assoc.
2004 Jul;43(4):381-385.
Monocyte Chemoattractant Protein-1(MCP1)-2518 Polymorphism and Major Depressive Disorder
- Affiliations
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- 1Department of Psychiatry, Kangnam St. Mary's Hospital, Korea. knpsy@catholic.ac.kr
- 2Department of Psychiatry, St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
Abstract
- OBJECT: This study was designed to examine the association between monocyte chemoattractant protein-1 (MCP1) -2518 polymorphism and major depressive disorder (MDD).
METHODS
Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method.
RESULTS
Genotype and allele distributions in patients with MDD were significantly different from those of the controls. In particular, subjects with the allele A were found to have an increased risk of MDD.
CONCLUSION
The present study suggests that the MCP1 -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.
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