J Korean Neuropsychiatr Assoc.
1999 Jul;38(4):873-880.
Regulation of MAPK Activity by Seizure-induced MKP-1 in Rat Hippocampus
- Affiliations
-
- 1Department of Psychiatry Sung-Kyun-Kwan University College of Medicine, Suwon, Korea.
- 2Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Neuropsychiatry, Gil Medical Center, Gachon Medical College, Incheon, Korea.
- 4Department of Biochemistry, Seoul National University College of Medicine, Seoul, Korea.
- 5Department of Biochemistry & Molecular Biology, Sung-Kyun-Kwan University College of Medicine, Suwon, Korea.
Abstract
- OBJECTIVES: Both electroconvulsive shock(ECS) and kainic acid-induced seizures activate mitogenactivated protein kinases(MAPKs)in rat hippocampus. They can also induce the expression of MAPK phosphatase-1(MKP-1)in rat hippocampus. MKP-1 is known as a specific MAPK deactivator. This study aimed to elucidate the role of MKP-1 in the deactivation of MAPKs in rat hippocampus.
METHODS
In order to induce MKP-1 in the hippocampus, ECS was given to the rats. At the time points when MKP-1 was sufficiently induced, the second ECS was given to them and the subsequent phosphorylation or activation of MAPKs were measured in the hippocampus. A second group of rats were injected with kainic acid and the relationship between MKP-1 expression and MAPK phosphorylation was examined in their hippocampi.
RESULTS
The expression of MKP-1 did not influence the phosphorylation or activation of MAPKs following ECS in rat hippocampus. Kainic acid-induced expression of MKP-1 did not significantly reduce the phosphorylation of MAPKs.
CONCLUSION
MKP-1 did not play a significant role in the deactivation of MAPKs which were activated by ECS or kainic acid in rat hippocampus.
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