Skip Navigation
Skip to contents
Results by Year

View Wide

Filter

ARTICLE TYPE

PUBLICATION DATE

118 results
Display

Morin Prevents Granule Cell Dispersion and Neurotoxicity via Suppression of mTORC1 in a Kainic Acid-induced Seizure Model

Lee JM, Hong J, Moon GJ, Jung UJ, Won SY, Kim SR

An abnormal reorganization of the dentate gyrus and neurotoxic events are important phenotypes in the hippocampus of patients with temporal lobe epilepsy (TLE). The effects of morin, a bioflavonoid constituent...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Atorvastatin pretreatment attenuates kainic acid-induced hippocampal neuronal death via regulation of lipocalin-2-associated neuroinflammation

Jin Z, Jung Y, Yi CO, Lee JY, Jeong EA, Lee JE, Park KJ, Kwon OY, Lim BH, Choi NC, Roh GS

Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Antiepileptic and anti-neuroinflammatory effects of red ginseng in an intrahippocampal kainic acid model of temporal lobe epilepsy demonstrated by electroencephalography

Kim JY, Kim JH, Lee HJ, Kim SH, Jung YJ, Lee HY, Kim HJ, Kim SY

BACKGROUND: Chronic inflammation can lower the seizure threshold and have influence on epileptogenesis. The components of red ginseng (RG) have anti-inflammatory effects. The abundance of peripherally derived immune cells in...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Cilostazol attenuates kainic acid-induced hippocampal cell death

Park YS, Jin Z, Jeong EA, Yi CO, Lee JY, Park IS, Roh GS

Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Astrocytic Expression of CTMP Following an Excitotoxic Lesion in the Mouse Hippocampus

Shin N, Yi MH, Kim S, Baek H, Triantafillu UL, Park J, Kim DW

Akt (also known as protein kinase B, PKB) has been seen to play a role in astrocyte activation of neuroprotection; however, the underlying mechanism on deregulation of Akt signaling in...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Beneficial Effects of Silibinin Against Kainic Acid-induced Neurotoxicity in the Hippocampus in vivo

Kim S, Jung UJ, Oh YS, Jeon MT, Kim HJ, Shin WH, Hong J, Kim SR

Silibinin, an active constituent of silymarin extracted from milk thistle, has been previously reported to confer protection to the adult brain against neurodegeneration. However, its effects against epileptic seizures have...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Neuroprotective Effects of SYM 2081, Targeting Kainate Receptors in the Neonatal Hypoxic-Ischemic Brain Injury

Lee JH, Lee EJ, Jang YY, Jeong JE, Chung HL, Kim WT

PURPOSE: Glutamate induced excitotoxicity has been implicated as a major factor of central neuronal death in neonatal hypoxic-ischemic (HI) injury. Kainate receptors (KARs) are one of glutamatergic receptors involving glutamate...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Kainic Acid Treatment Increases Ca²⁺-mediated Neurotoxicity in the Mouse Hippocampus

Lee JE

Kainic acid (KA)-induced neuronal cell death is associated with intracellular Ca²⁺ influx. However, it is unknown whether Lyn/Btk pathway is involved in the Ca²⁺-mediated neurotoxicity and neuronal death induced by...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
A Model of Glial Scarring Analogous to the Environment of a Traumatically Injured Spinal Cord Using Kainate

Yoo JY, Hwang CH, Hong HN

OBJECTIVE: To develop an in vitro model analogous to the environment of traumatic spinal cord injury (SCI), the authors evaluated change of astrogliosis following treatments with kainate and/or scratch, and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Growth Differentiation Factor 15 Expression in Astrocytes After Excitotoxic Lesion in the Mouse Hippocampus

Yi MH, Zhang E, Baek H, Kim S, Shin N, Kang JW, Lee S, Oh SH, Kim DW

Growth differentiation factor 15 (GDF15) is, a member of the transforming growth factor beta (TGF-beta) superfamily of proteins. Although GDF15 is well established as a potent neurotrophic factor for neurons,...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effect of Pioglitazone on Excitotoxic Neuronal Damage in the Mouse Hippocampus

Lee CH, Yi MH, Chae DJ, Zhang E, Oh SH, Kim DW

Pioglitazone (PGZ), a synthetic peroxisome proliferator-activated receptor gamma agonist, is known to regulate inflammatory process and to have neuroprotective effects against neurological disorders. In the present study, we examined the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Low Non-NMDA Receptor Current Density as Possible Protection Mechanism from Neurotoxicity of Circulating Glutamate on Subfornical Organ Neurons in Rats

Chong W, Kim SN, Han SK, Lee SY, Ryu PD

The subfornical organ (SFO) is one of circumventricular organs characterized by the lack of a normal blood brain barrier. The SFO neurons are exposed to circulating glutamate (60~100 microM), which...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Intracerebroventricular Kainic Acid-Induced Damage Affects Blood Glucose Level in d-glucose-fed Mouse Model

Kim CH, Hong JS

We have previously reported that the intracerebroventricular (i.c.v.) administration of kainic acid (KA) results in significant neuronal damage on the hippocampal CA3 region. In this study, we examined possible changes...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Alpha1-Adrenoceptor Antagonists Improve Memory by Activating N-methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus

Kim CH, Ko IG, Kim SE, Shin MS, Kang YH, Cho JW, Shin KM, Kim CJ, Lim BV, Kim KH

PURPOSE: Alpha1 (alpha1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Glycyrrhizin Attenuates Kainic Acid-Induced Neuronal Cell Death in the Mouse Hippocampus

Luo L, Jin Y, Kim ID, Lee JK

Glycyrrhizin (GL), a triterpene that is present in the roots and rhizomes of licorice (Glycyrrhiza glabra), has been reported to have anti-inflammatory and anti-viral effects. Recently, we demonstrated that GL...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Esculetin inhibits N-methyl-D-aspartate neurotoxicity via glutathione preservation in primary cortical cultures

Lee CR, Shin EJ, Kim HC, Choi YS, Shin T, Wie MB

Recently, loss of endogenous glutathione during N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxic injury, and the resultant overproduction of reactive oxygen species (ROS) through an arachidonic acid cascade process in brain, have been...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
ID4 mediates proliferation of astrocytes after excitotoxic damage in the mouse hippocampus

Lee YS, Kang JW, Lee YH, Kim DW

Inhibitor of DNA binding (ID) proteins bind to and inhibit the function of basic helix-loop-helix transcription factors, including those that regulate proliferation and differentiation during development. However, little is known...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
The Ketogenic Diet Suppresses the Cathepsin E Expression Induced by Kainic Acid in the Rat Brain

Jeong HJ, Kim H, Kim YK, Park SK, Kang DW, Yoon D

PURPOSE: The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, we analyzed the changes in gene...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Phosphorylation of 14-3-3zeta at serine 58 and neurodegeneration following kainic acid-induced excitotoxicity

Jeong EA, Jeon BT, Kim JB, Kim JS, Cho YW, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS

Oxidative stress-induced cell death leads to phosphorylation of 14-3-3zeta at serine 58. 14-3-3zeta is detected at significant levels in cerebrospinal fluid after kainic acid (KA)-induced seizures. Here we examined temporal...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Neurotoxicity Screening in a Multipotent Neural Stem Cell Line Established from the Mouse Brain

Choi YS, Lee MC, Kim HS, Lee KH, Park YG, Kim HK, Jeong HS, Kim MK, Woo YJ, Kim SU, Ryu JK, Choi HB

Neural stem cells (NSCs) have mainly been applied to neurodegeneration in some medically intractable neurologic diseases. In this study, we established a novel NSC line and investigated the cytotoxic responses...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr