J Korean Pediatr Soc.
2000 Jul;43(7):913-919.
Teratogenic Effect of Dopamine on the Embryonic Chick Heart
- Affiliations
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- 1Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea.
Abstract
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PURPOSE: To investigate the teratogenic potential of dopamine using a topical method of
application to the developing Korean native chick embryo.
METHODS
A 5 pg(0.05cc) of dopamine was applied to a 3-days-old chick embryo and the same amount of saline solution was applied as control. The embryo was then returned to the incubator and monitored. After 3 weeks the embryo was sacrificed and examined for cardiovascular malformation.
RESULTS
The survival rate of the dopamine-administered group was not significantly lower than that of the control group(32.2% vs 41.5%). Cardiovascular malformation rates between the two groups were 14.3% and 2.6%, respectively. The dopamine-administered group had significant higher malformation rate(P=0.049). The type of malformation was ventricular septal defect and no aortic arch anomaly. In the control group, one trabecular type was observed. In the dopamineadministered group, malformations were 3 trabecular ventricular septal defects(VSDs), 2 infracrista VSDs, 1 inlet VSD and 1 large supracrista VSD. These
results
were quite different from each other.
CONCLUSION
We proposed that low doses of dopamine influence the cardiovascular morphogenesis through -1 receptor weakly or through dopaminergic receptor.
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