J Korean Pediatr Soc.  1997 Jul;40(7):1021-1025.

A Case of Chronic Granulomatous Disease Which is Improved by Interferon- Therapy

Affiliations
  • 1Department of Pediatrics, Kangbuk Samsung Hospital, Seoul, Korea.

Abstract

Chronic granulomatous disease is a group of rare disorders characterized by a disease of oxidative metabolism of phagocytes with deficit of antimicrobial activity. Also, it has clinical features of chronic pyogenic infection, granuloma formation, hypergammaglobulinemia, anemia and leukocytosis.We experienced a case of chronic granulomatous disease with chronic recurrent infection, hypergammaglobulinemia and liver abscess. It was confirmed by modified NBT test. The result of patient's NBT test was less than 11%. The patient received subcutaneous injection of interferon-gamma, 200 million unit (0.1mg/m2 of body surface area per dose), on three consecutive days per week for 3 weeks and her symptom was improved. Then, we report a case of chronic granulomatous disease which is improved by interferon- therapy with brief review of literature.

Keyword

Chronic granulomatous disease; Interferon- therapy

MeSH Terms

Anemia
Body Surface Area
Granuloma
Granulomatous Disease, Chronic*
Humans
Hypergammaglobulinemia
Injections, Subcutaneous
Interferon-gamma
Liver Abscess
Metabolism
Phagocytes
Interferon-gamma
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