J Korean Assoc Maxillofac Plast Reconstr Surg.  2001 Sep;23(5):435-446.

Rapid Spread NK/T-Cell Malignant Lymphoma of Maxilla

• Kim WK

Abstract

Natural Killer/T-cell(NK/TC) lymphoma is a rare disease of oral and maxillofacial region with an aggressive clinical course, showed unusual clinical manifestations. Prognosis is generally poor and the disease is invariably fatal after systemic dissemination. A case of nasal NK/TC non-Hodgkin's lymphoma in the left maxilla that showed unusual clinical manifestations and a fulminant course of disease, are described with literature reviews. A 81-year-old female patient presented with rapidly growing ulceration and general malaise after extraction of right upper second premolar. NK/TC lymphoma was subsequently detected by biopsy. rapid and wide invasion from maxilla to mandible developed within 10 days and multiple metastasis to whole body was after a few weeks. Although the time relationship is not clear, local invasion and multiple metastasis could be dissemination from localized disease of NK/TC. As seen in my case, the course can be excessively aggressive and fulminant even though it first appeared as a localized ulcerative lesion. She is expired 2 months after biopsy. Positivity of immunohistochemical stain (CD56, LCA, UCHL-1, CD3), which is a specific characteristic of NK/TC, may serve as a factor showing a poor prognosis of a malignant lymphoma NK/TC malignant lymphomas, Immunohistochemical stain

MeSH Terms

Aged, 80 and over
Bicuspid
Biopsy
Female
Humans
Lymphoma*
Lymphoma, Non-Hodgkin
Mandible
Maxilla*
Neoplasm Metastasis
Prognosis
Rare Diseases
Ulcer