J Korean Surg Soc.  2012 Jun;82(6):385-388.

Parathyroid carcinoma with lung metastasis in a thirteen-year-old girl

• Kim YS

Abstract

Parathyroid carcinoma is a rare disease in pediatric patients. We present a case of a 13-year-old girl who presented to the Thyroid Department for an asymptomatic palpable neck mass for 1 year. The high levels of calcium, ionized calcium, and parathyroid hormone level along with parathyroid scintigraphy studies suggested primary hyperparathyroidism. Parathyroid carcinoma was confirmed by biopsy and pathologic examination after resection. Six months postoperatively, persistent hypercalcemia and multiple lung metastases were found on computed tomography. Bilateral lung wedge resection was performed. En bloc resection for primary parathyroid carcinoma and aggressive resection of metastatic disease is the most effective treatment to control hypercalcemia.

Keyword

Parathyroid carcinoma; Lung metastases; Child

MeSH Terms

Adolescent
Biopsy
Calcium
Child
Humans
Hypercalcemia
Hyperparathyroidism, Primary
Lung
Neck
Neoplasm Metastasis
Parathyroid Hormone
Parathyroid Neoplasms
Rare Diseases
Thyroid Gland
Calcium
Parathyroid Hormone

Figure

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  Fig. 1 Well-defined mass (4 cm) with multifocal cystic area in the right thyroid gland.

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  Fig. 2 (A) Capsular invasion and thick fibrous bands in parathyroid carcinoma (H&E, ×40). (B) Parathyroid carcinoma exhibiting vascular invasion (H&E, ×400).

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  Fig. 3 Hematogenous metastases in lung.

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