J Korean Soc Pediatr Nephrol.
2007 Oct;11(2):288-293.
Two Cases of Thrombotic Thrombocytopenic Purpura in Systemic Lupus Erythematosus
- Affiliations
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- 1Department of Pediatrics, College of Medicine Busan National University, Busan, Korea. suyung@pusan.ac.kr
- 2Department of Laboratory Medicine, College of Medicine Busan National University, Busan, Korea.
Abstract
- Thrombotic thrombocytopenic purpura(TTP) is a rare but life-threatening multi-system disorder characterized by the classic pentad of clinical features that includes fever, microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities and renal dysfunction. TTP has been rarely reported to simultaneously present with systemic lupus erythematosus (SLE). While it is important to distinguish between the two diseases of therapeutic implication, cases of concurrent TTP and SLE help to elucidate the pathophysiology that underlies each condition. We describe two adolescents with synchronous TTP and SLE, and review the literature.
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