Tuberc Respir Dis.  2011 Nov;71(5):349-354.

E6 Oncoprotein Expression in Non-Small Cell Lung Cancer Patients

• Cho JN
• Yoon SY
• Hyun DS

Abstract

BACKGROUND
Lung cancer is the leading cause of cancer deaths in the world. Human papillomavirus (HPV) infection and E6 oncoprotein expression are known risk factors for the development of non-small cell lung cancer (NSCLC). This study was performed to evaluate the prevalence of HPV 16/18 E6 oncoprotein expression in patients with NSCLC.
METHODS
Immunohistochemical stains of the HPV 16/18 E6 oncoprotein were performed in tumor tissues from 68 patients with NSCLC who underwent curative surgery from March 2006 to November 2008.
RESULTS
The E6 oncoprotein was expressed in 29.4%of patients with NSCLC and a statistical analysis revealed that E6 oncoprotein expression was significantly higher in females (p=0.028), never smokers (p=0.045), and patients with adenocarcinoma (p=0.022) than that in other patients.
CONCLUSION
The E6 oncoprotein was expressed in 29.4% of patients with NSCLC. Further studies detecting HPV infection and E6 oncoprotein expression in never smoking patients with NSCLC are needed.

Keyword

Lung Neoplasms; oncogene protein E6, human papillomavirus type 18

MeSH Terms

Adenocarcinoma
Carcinoma, Non-Small-Cell Lung
Coloring Agents
Female
Humans
Lung Neoplasms
Oncogene Proteins, Viral
Prevalence
Risk Factors
Smoke
Smoking
Coloring Agents
Oncogene Proteins, Viral
Smoke