Pediatr Gastroenterol Hepatol Nutr.  2013 Jun;16(2):89-94.

Increase in Aminotransferase Levels during Urinary Tract Infections in Children

• Park JY
• Ko KO
• Lim JW
• Cheon EJ
• Yoon JM

Abstract

PURPOSE
The aim of this study was to evaluate the prevalence of increased aminotransferase levels and to identify associated factors in children admitted to hospital with urinary tract infections (UTIs).
METHODS
The study included children with a diagnosis of UTI who were admitted to the Konyang University Hospital from January 2007 to May 2011. The total number of patients was 249 and the mean age was 15.88+/-28.21 months. UTI was defined as a positive urine culture (>105/colony forming unit [CFU]) with pyrexia. Patients were treated by intravenous antibiotics, such as ampicillin/sulbactam, aminoglycoside, cephalosporins or vancomycin. Patients with neonatal jaundice or other liver disease were excluded. We investigated the relationship of aminotransferase levels with the type of antibiotic, degree of vesicoureteral reflux (VUR), and causative organisms.
RESULTS
Children with increased aminotransferase levels were younger than those with normal levels (p=0.001), but white blood cell count, platelet count, causative organisms, type of antibiotics and presence of VUR were not associated with aminotransferase levels. Aminotransferase levels became normal within 1 month after discharge without special measures, except in 1 case.
CONCLUSION
We found that many children with UTI have abnormal aminotransferase levels. In most cases, this change is mild and self-limiting. We conclude that increased aminotransferase level increase during UTI do not require unnecessary tests and excessive treatment.

Keyword

Urinary tract infections; Aminotransferase abnormality; Liver function tests; Sepsis

MeSH Terms

Anti-Bacterial Agents
Cephalosporins
Child
Fever
Humans
Infant, Newborn
Jaundice, Neonatal
Leukocyte Count
Liver Diseases
Liver Function Tests
Platelet Count
Prevalence
Sepsis
Urinary Tract
Urinary Tract Infections
Vancomycin
Vesico-Ureteral Reflux
Anti-Bacterial Agents
Cephalosporins
Vancomycin

Figure

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  Fig. 1 Aminotransferase levels for total observation period. (A) Serum aspartate aminotransferase (AST) level and (B) serum alanine aminotransferase (ALT) level for follow up period. The follow-up period was about two months. The aminotransferase levels became normal ranges for 2 months.

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