Pediatr Allergy Respir Dis.  2011 Sep;21(3):197-206.

Prevalence of Allergic Diseases in Children according to Mode of Delivery

Affiliations
  • 1Department of Pediatrics, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
  • 2Department of Pediatrics, Bundang CHA Hospital, CHA University School of Medicine, Seongnam, Korea.
  • 3Department of Pediatrics, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
  • 4Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 5Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 6Department of Pediatrics, Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
  • 7Department of Pediatrics, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 8Department of Pediatrics, Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea. kwkim@yuhs.ac

Abstract

PURPOSE
It has been suggested that caesarean section is a risk factor for allergic diseases under the 'hygiene hypothesis', but it remains controversial. In this study, we examined the association between mode of delivery and development of allergic diseases.
METHODS
The Korean International Study of Asthma and Allergies in Childhood questionnaire was used to survey 8,404 elementary and middle-school students in Seoul between April and October 2008. We categorized children into a caesarean section group and a vaginal delivery group, and surveyed the prevalence of asthma, allergic rhinitis, and atopic dermatitis.
RESULTS
No differences in the prevalence of "wheeze ever" (P=0.418), "wheezing the last 12 months" (P=0.152), and "diagnosis of asthma ever" (P=0.382) were observed between the caesarean section group and the vaginal delivery group. The prevalence of "rhinitis ever" (P=0.609), "rhinitis the last 12 months" (P=0.788), and "diagnosis of allergic rhinitis ever" (P=0.700) was also similar between the two groups. The prevalence of "itchy eczema ever" (P=0.065), "itchy eczema last 12 months" (P=0.381), and a "diagnosis of atopic dermatitis ever" (P=0.162) also did not show any differences between the two groups. However, in subjects with a family history of allergic disease, the caesarean section group had the higher prevalence of "diagnosis of asthma ever" (11.3% vs. 9.2%, P=0.032) than that in the vaginal delivery group.
CONCLUSION
We found an association between mode of delivery and the subsequent development of asthma in children with a family history of allergic disease in Seoul, Korea.

Keyword

Caesarean section; Mode of delivery; Children; Asthma; Allergic rhinitis; Atopic dermatitis

MeSH Terms

Asthma
Cesarean Section
Child
Dermatitis, Atopic
Eczema
Female
Humans
Hypersensitivity
Korea
Pregnancy
Prevalence
Surveys and Questionnaires
Rhinitis
Rhinitis, Allergic, Perennial
Risk Factors

Reference

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