Mycobiology.  2010 Mar;38(1):46-51.

The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage

Affiliations
  • 1Department of Microbiology, Dong-A University College of Medicine, Busan 604-714, Korea. mhjeong@dau.ac.kr
  • 2Cheong-Won Farm, Gimhae 621-843, Korea.
  • 3Deartment of Microbiology, Pusan National University College of Natural Sciences, Busan 609-735, Korea.

Abstract

The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release in RAW 264.7 cells. The treatment of macrophages with various concentrations of hot CMWE significantly reduced LPS-induced production as well as NO, TNF-alpha and IL-6 secretion in a concentration-dependent manner. These results suggest that CMWE have potent inhibitory effects on the production of these inflammatory mediators.

Keyword

Anti-inflammatory activity; Cordyceps militaris; Lipopolysaccharide; Nitric oxide; Pro-inflammatory cytokines; RAW 264.7 cell

MeSH Terms

Cordyceps
Fruit
Interleukin-6
Macrophages
Nitric Oxide
Tumor Necrosis Factor-alpha
Water
Interleukin-6
Nitric Oxide
Tumor Necrosis Factor-alpha
Water
Full Text Links
  • MB
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr