Korean J Urol.  2008 Jul;49(7):647-649.

A Primary Large Cell Neuroendocrine Carcinoma of the Urinary Bladder in a 19-year-old Man

• Kwon WA
• Ha YS
• Lee OJ
• Kim YJ
• Yun SJ
• Lee SC
• Kim WJ

Abstract

Primary large cell neuroendocrine carcinomas of the urinary bladder are extremely rare. To date, only six cases of large cell neuroendocrine carcinoma have been reported. We present a case of a 19-year-old man who presented with gross hematuria and who was subsequently found to have a solitary tumor on the dome of the urinary bladder. The patient underwent transurethral resection of the bladder tumor for histological confirmation. A diagnosis of large cell neuroendocrine carcinoma was made based upon immunohistochemical reactivity for synaptophysin and CD56. Based on the pathologic diagnosis, he subsequently had a partial cystectomy. Histologically, the tumor penetrated the perivesical fat. It has now been 6 months since the surgery, and the patient is preparing to receive his 5th cycle of chemotherapy. There is no evidence of tumor recurrence or metastasis.

Keyword

Carcinoma; large cell; Neuroendocrine carcinoma; Urinary bladder

MeSH Terms

Carcinoma, Neuroendocrine
Cystectomy
Hematuria
Humans
Recurrence
Synaptophysin
Urinary Bladder
Urinary Bladder Neoplasms
Young Adult
Synaptophysin

Figure

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  Fig. 1. Computed tomography scan shows a 4x4cm sized intravesical polypoid enhancing mass with internal calcification in the urinary bladder.

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  Fig. 2. The tumor consists of polygonal, large, and pleomorphic cells arranged in a solid growth pattern. Frequent mitoses are observed (H&E, x400).

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  Fig. 3. The tumor cells show positive immunoreactivity for synaptophysin (x400).

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