Korean J Med.  2003 Apr;64(4):429-434.

The Relationship between the serum intercellular adhesion molecule-1 level and the prognosis of the disease in lung cancer

• Shin HS
• Jung CH
• Park HD
• Lee SS

Abstract

BACKGROUND: Adhesion molecule is related to cell-cell interaction and inflammatory interaction. In addition, adhesive interactions between tumor cells and adjacent cells and/or extracellular matrix are important role in the complex process of tumor growth and develpment. Of these adhesion molecules, expression of intercellular adhesion molecule-1 (ICAM-1) have been identified in colon cancer, bladder cancer, lung cancer, melanoma, pancreatic cancer, hepatocellular carcinoma. In the current study, we analyzed serum ICAM-1 concentrations to investigate the relationship between the sICAM-1 level and the prognosis of the disease in patients with lung cancer
METHODS
Serum sICAM-1 was measured in 84 patients with lung cancer according to the pathologic types and clinical staging using ICAM-1 ELISA kit. The Kaplan-Meier method was used to analyse survival time.
RESULTS
There was no difference in sICAM-1 concentration among the stage of lung cancer. And no difference was observed among histologic tumor types with regard to sICAM-1 concentration. The overall survival of patients with low sICAM-1 concentration (<306 ng/mL) were longer than that of patients with high concentration (>or=306 ng/mL) in non-small cell lung cancer patients, but no difference was observed in small cell lung cancer patients.
CONCLUSION
These results suggest that high levels of sICAM-1 reflect the poor prognosis of patients with non-small cell lung cancer.

Keyword

Lung cancer; ICAM-1; Soluble ICAM-1

MeSH Terms

Adhesives
Carcinoma, Hepatocellular
Carcinoma, Non-Small-Cell Lung
Colonic Neoplasms
Enzyme-Linked Immunosorbent Assay
Extracellular Matrix
Humans
Intercellular Adhesion Molecule-1*
Lung Neoplasms*
Lung*
Melanoma
Pancreatic Neoplasms
Prognosis*
Small Cell Lung Carcinoma
Urinary Bladder Neoplasms
Adhesives
Intercellular Adhesion Molecule-1