Korean J Infect Dis.  2001 Jun;33(3):157-164.

Seroepidemiology of Mumps IgG Antibody on Primary School Children in Kyonggi Province, 1996 and 1999

Affiliations
  • 1Laboratory of Respiratory Viruses, Division of Epidemiology, National Institute of Health.
  • 2Department of Preventive Medicine, College of Medicine, Hanyang University.
  • 3Department of Preventive Medicine, Eulji University School of Medicine.
  • 4Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.

Abstract

BACKGROUND: Although massive use of live attenuated mumps virus vaccines successfully reduced the incidence of mumps virus infection worldwide, mumps outbreaks have not been completely eliminated, even in vaccinated populations. In recent years, the incidence of mumps has been remarkably increased in Korea. This study was designed to evaluate the recent seroprevalence rate of mumps IgG among children in Kyonggi province at 1996 and 1999. METHODS: Study population included students from 8 elementary schools in Kyonggi province. Serum samples were collected twice at 1996 and 1999 and tested for mumps-specific antibody by enzyme-linked immunosorbent assay (ELISA). We also conducted a questionnaire survey on the parents and collected the records including history of vaccination and mumps infection. RESULTS: The seropositive rates against mumps were 89.47% and 89.74% at 1996 and 1999, respectively, and they were not significantly different when compared to age, sex, and region. Although the first vaccination rates were 92.17% and 92.25% at 1996 and 1999, respectively, the second vaccination rates were only 37.89% and 38.03% at 1996 and 1999, respectively. Infection rate showed no significant difference between vaccinated groups and nonvaccinated groups. Seropositive rate of infected group was higher than that of noninfected group but it was not significantly different between the vaccinated and the nonvaccinated. CONCLUSIONS: This study showed the seropositive rate and vaccination against mumps in children. There were no significant relationships between vaccination and infection. Therefore, it seems likely that the vaccination is not fully protective against mumps infection. This study will be helpful for the establishment of guideline for prevention and treatment of mumps in Korea.

Keyword

Mumps; Immunity; Vaccination

MeSH Terms

Child*
Disease Outbreaks
Enzyme-Linked Immunosorbent Assay
Gyeonggi-do*
Humans
Immunoglobulin G*
Incidence
Korea
Mumps virus
Mumps*
Parents
Seroepidemiologic Studies
Vaccination
Vaccines
Surveys and Questionnaires
Immunoglobulin G
Vaccines
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