Korean J Dermatol.  2003 May;41(5):630-633.

A Case of Acute Generalized Exanthematous Pustulosis with Erythema Multiforme-like lesions

• Yang JS
• Lee JH
• Song JY
• Kim TY
• Lee JY

Abstract

Acute generalized exanthematous pustulosis(AGEP) is a disease entity caused mostly by drugs or viral infections. Clinically, it manifests as generalized erythema and tiny pustules with fever, but may manifest targetoid lesions, purpura, edema, blisters and mucosal erosions in addition to pustules. We describe a case of AGEP with erythema multiforme-like features in a 46 year old woman who presented with acute onset of high fever and a noticeably polymorphic eruption consisting of numerous tiny pustules on erythematous bases, edematous targetoid lesions and purpuric lesions. The histology revealed subcorneal neutrophilic pustules on the tiny pustular lesions and markedly papillary dermal edema on the erythema multiforme-like lesions. Systemic corticosteroid and antihistamines were initiated, resulting in rapid resolution without recurrence.

Keyword

Acute generalized exanthematous pustulosis; Erythema multiforme-like features

MeSH Terms

Acute Generalized Exanthematous Pustulosis*
Blister
Edema
Erythema*
Female
Fever
Histamine Antagonists
Humans
Middle Aged
Neutrophils
Purpura
Recurrence
Histamine Antagonists