Korean J Dermatol.  1998 Feb;36(1):125-128.

A Case of Acute Generalized Exanthematous Pustulosis

• Lee SJ
• Chang SN
• Park WH

Abstract

Acute generalized exanthematous pustulosis(AGEP) is a disease entity caused mostly by drugs or viral infections. Clinically it manifests as generalized erythema, erythema multiforme and amicrobial pustules with fever. Histologically, AGEP is composed of neutrophilic subcorneal and spongiform pustules. A 70-year-old female, with no personal or family history of psoriasis, was given medication including diltiazem for hypertension. Fourteen days after taking the medications, pustular eruptions appeared on the face and rapidly spread to the trunk and limbs. A Laboratory examination revealed neutrophilic leukocytosis and an elevated erythrocyte sedimentation rate. The skin biopsy showed subcorneal and spongiform pustules. We report here a case of AGEP probably due to diltiazem.

Keyword

Acute generalized exanthematous pustulosis; Diltiazem

MeSH Terms

Acute Generalized Exanthematous Pustulosis*
Aged
Biopsy
Blood Sedimentation
Diltiazem
Erythema
Erythema Multiforme
Extremities
Female
Fever
Humans
Hypertension
Leukocytosis
Neutrophils
Psoriasis
Skin
Diltiazem