Korean J Dermatol.  2009 Sep;47(9):1098-1101.

Acute Generalized Exanthematous Pustulosis Induced by Itraconazole

• Kang MC
• Kim SA
• Lee KS
• Cho JW

Abstract

A 40-year-old male had a history of tinea pedis, which had been treated with itraconazole. One week later fever and pruritic, multiple, symmetric, erythematous papules developed, some of which became confluent, producing plaques on his face, trunk, and limbs. The skin biopsy showed subcorneal and spongiform pustules. One month later we had patch tests with itraconazole and other drugs. The result of the patch test using itraconazole was a (++) reaction that showed erythematous macules, papulovesicles and patch (after 48 hours). So, we report here a rare case of acute generalized exanthematous pustulosis (AGEP) that manifests as generalized erythema, erythema multiforme and amicrobial pustules with fever due to itraconazole.

Keyword

Acute generalized exanthematous pustulosis; Itraconazole

MeSH Terms

Acute Generalized Exanthematous Pustulosis
Adult
Biopsy
Erythema
Erythema Multiforme
Extremities
Fever
Humans
Itraconazole
Male
Patch Tests
Skin
Tinea Pedis
Itraconazole