Korean J Dermatol.
2007 Jun;45(6):635-639.
Two Cases of Antituberculosis Drug-induced Hypersensitivity Syndrome
- Affiliations
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- 1Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. daehun@snu.ac.kr
- 2Department of Internal Medicine, The Catholic University of Korea College of Medicine1, Seoul, Korea.
Abstract
- Drug-induced hypersensitivity syndrome is a rare, but severe, life-threatening disease with multiorgan failure. Aromatic antiepileptic drugs are frequent causes of this syndrome. The association of the human herpes virus-6 has been recently reported in patients with drug-induced hypersensitivity syndrome. We report two patients who were diagnosed as having antituberculosis drug-induced hypersensitivity syndrome based on clinical course and laboratory data. In addition, human herpes virus-6 DNA was detected by polymerase chain reaction in peripheral blood mononuclear cells and the serum. There was a favorable outcome after discontinuation of the causative drug, plus corticosteroid therapy. After the treatment, human herpes virus-6 DNA was not detected by polymerase chain reaction. This is the first report of antituberculosis drug-induced hypersensitivity syndrome associated with reactivation of human herpes virus-6.
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