Allergy Asthma Immunol Res.  2014 May;6(3):270-272. 10.4168/aair.2014.6.3.270.

Drug Rash With Eosinophilia and Systemic Symptoms Syndrome Induced by Chloral Hydrate in Early Childhood

• Yoo SD
• Kim SG
• Kim SH
• Kim HY

• KMID: 2260692
• DOI: http://doi.org/10.4168/aair.2014.6.3.270

Abstract

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome (DIHS), is a rare, acute and severe life-threatening systemic disease. DRESS syndrome is characterized by fever, lymphadenopathy, rash, hypereosinophilia and involvement of systemic organs. The most commonly implicated drugs are anticonvulsants, sulfonamides and allopurinol. Chloral hydrate is a sedative and hypnotic drug frequently used in pediatric patients. We first report a case of DRESS syndrome induced by chloral hydrate in a 14-month-old female.

Keyword

Drug hypersensitivity; chloral hydrate

MeSH Terms

Allopurinol
Anticonvulsants
Chloral Hydrate*
Drug Hypersensitivity
Drug Hypersensitivity Syndrome
Eosinophilia*
Exanthema*
Female
Fever
Humans
Hypersensitivity
Infant
Lymphatic Diseases
Sulfonamides
Allopurinol
Anticonvulsants
Chloral Hydrate
Sulfonamides

Figure

• 

  Fig. 1 (A) Clinical photographs show generalized edematous features & systemic morbilliform rash as DRESS syndrome. (B) Sternostomy wounds were observed and (C) hepatosplenomegaly was detected.

• 

  Fig. 2 Chest radiograph shows increased ground glass opacity in the whole lung field, which represents interstitial pneumonia.

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