Korean J Dermatol.  2009 Oct;47(10):1149-1153.

A Case of Primary Cutaneous Diffuse Large B-cell Lymphoma,Leg Type Which Metastasized to the Brain

• Kim YM
• Kim SK
• Lee SH
• Park YL
• Lee J
• Whang KU
• Chin S

Abstract

In the WHO-EORTC (World Health Organization-European Organization for Research and Treatment of Cancer) classification, the primary cutaneous B-cell lymphomas were divided into 4 groups: primary cutaneous marginal zone B-cell lymphoma, primary cutaneous follicle center cell lymphoma, primary cutaneous diffuse large B-cell lymphoma, other, and primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL LT). PCLBCL LT is known to have more aggressive clinical behavior and a worse prognosis than the other groups of primary cutaneous B-cell lymphomas. We report here on a case of PCLBCL LT in a 55-year-old male who presented witha multiple erythematous nodules on the right leg. After chemotherapy, the skin lesions had almost cleared, but afterward the tumor was revealed to have metastasized to the brain during 1 year.

Keyword

Leg type; Metastasis; Primary cutaneous diffuse large B-cell lymphoma; WHO-EORTC classification

MeSH Terms

B-Lymphocytes
Brain
Humans
Leg
Lymphoma
Lymphoma, B-Cell
Lymphoma, B-Cell, Marginal Zone
Male
Middle Aged
Neoplasm Metastasis
Prognosis
Skin
World Health Organization