Korean J Anesthesiol.  1994 Sep;27(9):1125-1131. 10.4097/kjae.1994.27.9.1125.

Vasodilating Effect of Sodium Nitroprusside, Nitroglycerin, and Isosorbide Dinitrate during Cardiopulmonary Bypass

• Lee YM
• Lee EJ
• Cho MW

• KMID: 2298888
• DOI: http://doi.org/10.4097/kjae.1994.27.9.1125

Abstract

We have studied the vasodilating effect of bolus doses of sodium nitroprusside (SNP), nitro- glycerin (NTG), and isosorbide dinitrate (ISDN) in 40 patients during cardiopulmonary bypass with a constant pump flow. Blood volume of the venous reservoir and mean arterial pressure were recorded for 10 minutes after drug administration to detect changes in venous capacitance and arteriolar resistance. SNP 500 ug decreased mean blood pressure significantly more than NTG and ISDN compared with placebo. NTG 500 ug decreased mean blood pressure transiently at 1-4 min but significantly reduced reservoir blood volume. ISDN 500 ug increased mean blood pressure after drug administration, decreased reservoir blood volume less than NTG. We could conclude that SNP was more effective arteriolar vasodilator than NTG and ISDN, but NTG and ISDN were effective as a venodilator during cardiopulmonary bypass.

Keyword

Vasodilator; Cardiopulmonary bypass; Blood pressure; Venous capacitance

MeSH Terms

Arterial Pressure
Blood Pressure
Blood Volume
Cardiopulmonary Bypass*
Glycerol
Humans
Isosorbide Dinitrate*
Isosorbide*
Nitroglycerin*
Nitroprusside*
Sodium*
Vascular Access Devices
Glycerol
Isosorbide
Isosorbide Dinitrate
Nitroglycerin
Nitroprusside
Sodium