Korean J Androl.  2012 Apr;30(1):40-44. 10.5534/kja.2012.30.1.40.

Impact of Nocturia on Abnormal Daytime Sleepiness in Men with Lower Urinary Tract Symptoms/Benign Prostate Hyperplasia

• Doo SW
• Lee HJ
• Yang WJ
• Ahn HC
• Kim JH
• Park SJ
• Ahn J
• Song YS

• KMID: 2298807
• DOI: http://doi.org/10.5534/kja.2012.30.1.40

Abstract

PURPOSE
Nocturia is one of the most bothersome lower urinary tract symptoms (LUTS). The aim of the present study is to determine whether severe-nocturia have impact on the abnormal daytime sleepiness in men with LUTS/benign prostate hyperplasia (BPH).
MATERIALS AND METHODS
Severe-nocturia was classified as twice or more per night. A total of 85 men met the criteria and constituted the study cohort. The patients had a detailed clinical evaluation, including a complete history, physical examination, urine analysis, urine culture, a digital rectal examination, serum prostate-specific antigen (PSA) level, prostate volume by transrectal ultrasonography, uroflowmetry and postvoid residual urine volume. LUTS and symptom-specific quality of life (QoL) were assessed using the IPSS. Patients were asked to complete an Epworth Sleepiness Scale questionnaire for daytime sleepiness.
RESULTS
43 patients had less than one, 42 patients had more than two episodes of nocturia. There was no significant difference of age, total prostate volume, PSA levels between patients with mild-nocturia and severe-nocturia. There was no significant difference of maximum flow rate (Qmax), voided volume and postvoid residual urine volume (PVR) between patients with mild-nocturia and severe-nocturia. There was significant decrease of total International Prostate Symptom Score (IPSS) scores and QoL index in patients with severe-nocturia compared in patients with mild-nocturia. The number of patients with abnormal daytime sleepiness in mild-nocturia and severe-nocturia were 4.7% (2/43), 16.7% (7/42), respectively (p<0.05). Regression coefficiency between percent of nocturia and total score of daytime sleepiness was significant (p<0.05) and regression coefficient (R) was 0.29.
CONCLUSIONS
Our results indicate that severe-nocturia had impact on the abnormal daytime sleepiness in patients with LUTS.

Keyword

Nocturia; Lower urinary tract symptoms; Sleep disorders

MeSH Terms

Cohort Studies
Digital Rectal Examination
Humans
Hyperplasia
Lower Urinary Tract Symptoms
Male
Nocturia
Physical Examination
Prostate
Prostate-Specific Antigen
Quality of Life
Surveys and Questionnaires
Sleep Wake Disorders
Urinary Tract
Prostate-Specific Antigen

Figure

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  Fig. 1. Daytime sleepiness. The number of patients with abnormal daytime sleepiness in with mild nocturia and with severe nocturia were 4.7% and 19.0%, respectively (Fisher's exact test, p<0.05).

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