Korean Diabetes J.  2008 Feb;32(1):1-6. 10.4093/kdj.2008.32.1.1.

Insulin Resistance in Polycystic Ovary Syndrome

Affiliations
  • 1Department of Internal Medicine, Ewha Womans University School of Medicine, Korea.

Abstract

Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in women of reproductive age and now recognized as an important metabolic and reproductive disorder. The majority of women with PCOS have insulin resistance and this is regarded to have a central etiological role in PCOS. Insulin resistance and concomitant hyperinsulinemia modifies reproductive function by driving androgen production, suppression of sex hormone-binding globulin (SHBG) and disruption of insulin signaling pathways in the central nervous system. Insulin resistance, together with defects in insulin secretion, confers markedly increased risk for type 2 diabetes mellitus and metabolic syndrome. There are post-binding defects in insulin receptor signaling, with selective resistance to insulin's metabolic actions and preserved other actions. Genetic and environmental abnormalities interact to produce peripheral insulin resistance in PCOS. The numerous in vivo and in vitro data supporting the central role of insulin resistance in the pathogenesis of PCOS have led a new therapy for PCOS with insulin-sensitizing agents.

Keyword

Polycystic ovary syndrome; Insulin resistance

MeSH Terms

Central Nervous System
Diabetes Mellitus, Type 2
Female
Humans
Hyperinsulinism
Insulin
Insulin Resistance
Polycystic Ovary Syndrome
Receptor, Insulin
Sex Hormone-Binding Globulin
Insulin
Receptor, Insulin
Sex Hormone-Binding Globulin

Cited by  2 articles

Hyperandrogenism in Women: Polycystic Ovary Syndrome
Yeon-Ah Sung
Hanyang Med Rev. 2012;32(4):197-202.    doi: 10.7599/hmr.2012.32.4.197.

Epidemiology and Diagnostic Criteria of Polycystic Ovary Syndrome
Hyejin Lee, Yeon-Ah Sung
J Korean Diabetes. 2015;16(3):189-193.    doi: 10.4093/jkd.2015.16.3.189.


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