Korean J Obstet Gynecol.  2003 Aug;46(8):1543-1548.

Study on the Insulin Resistance According to Obesity in the Patients with Polycystic Ovarian Syndrome

Affiliations
  • 1Department of Family Medicine, Samsung Cheil Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
  • 2Department of Internal Medicine, Samsung Cheil Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
  • 3Department of Obstetrics and Gynecology, Samsung Cheil Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.

Abstract


OBJECTIVE
Polycystic ovarian syndrome (PCOS) is a heterogenous dysfunctional endocrinologic disorder with unknown etiology, clinically characterized by obesity, chronic anovulation, masculinization and infertility. Recently, the association between polycystic ovarian syndrome and insulin resistance have been brought up and insulin resistance is one of the most important factor related to the development of obesity. However, not all polycystic ovarian syndrome patients are obese, it would give a clue to understanding pathophysiology of obesity and PCOS if insulin resistance could be classified according to the degree of obesity in PCOS. Thus, we performed this prospective study to know the relationship between insulin resistance and obesity in the patients with PCOS.
METHODS
Fourty eight polycystic ovary patients were included at Samsung Cheil Hospital from April to October 2002. These patients were grouped according to obeseness. HOMA index was used to evaluate insulin resistance calculated by using fasting blood sugar and serum insulin level.
RESULTS
Twenty patients (41%) were classified as obese group, twenty eight patients (59%) had normal body mass index. Increased insulin resistance was observed in the patients with polycystic ovarian syndrome. And it was significantly higher in the obese patients compared to the patients with normal body mass index (6.8+/-2.8 vs. 2.7+/-0.9, t-test, p<0.01).
CONCLUSION
For increased insulin resistance, immediate management would be needed in the patients of polycystic ovarian syndrome, especially combined with obesity.

Keyword

Polycystic ovarian syndrome; Obesity; Insulin resistance; HOMA index
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