Korean Circ J.  2000 Aug;30(8):1017-1023. 10.4070/kcj.2000.30.8.1017.

Correlation Between Serum Magnesium, Ionized Calcium and Plasma Renin Activity in Hypertensives

• Kim HS
• Kim BS
• Lee SI
• Kim KT
• Kim H
• Kang JH
• Lee MH
• Park JR

• KMID: 2298031
• DOI: http://doi.org/10.4070/kcj.2000.30.8.1017

Abstract

BACKGROUND AND OBJECTIVES: Previous studies reported that sodium and potassium play an important role in the pathogenesis of hypertension. Recently attention has been directed towards a possible role of the divalent cations such as calcium, and magnesium. Plasma renin activity is also known to be related to divalent cations heterogeneously. This study investigated the relationships between serum magnesium and ionized calcium and plasma renin activity.
MATERIALS AND METHODS
The subjects consisted of 27 essential hypertensive patients and 25 normotensive controls. Criteria for hypertensive group in this study were systolic blood pressure> or =140mmHg or a diastolic blood pressure > or =90mmHg (JNC-VI, 1997). Inclusion criteria were normal urinalysis, no history of systemic illness, no intake of antihypertensive drugs, and no recent intake of any other medication. We took magnesium-loading test for a reliable method of assessing possible magnesium deficiency.
RESULTS
There was no significant difference between two groups in serum Magnesium concentration and other electrolytes and plasma renin activity. There was significantly higher rate in hypertensives than in normotensives in magnesium retention(hypertensive vs. normotensive: 63.56+/-12.21% vs. 38.43+/-11.53%, P<0.001). There was significant differences in ionized calcium between high-renin and low-or normo-renin hypertensives(P<0.001). Plasma renin activity was correlated positively with serum ionized calcium in hypertensives(r=.8147; P<0.001).
CONCLUSION
These results suggest that plasma renin activity is a factor that can influence on serum ionized calcium in high-renin hypertensives.

MeSH Terms

Antihypertensive Agents
Blood Pressure
Calcium*
Cations, Divalent
Electrolytes
Humans
Hypertension
Magnesium Deficiency
Magnesium*
Plasma*
Potassium
Renin*
Sodium
Urinalysis
Antihypertensive Agents
Calcium
Cations, Divalent
Electrolytes
Magnesium
Potassium
Renin
Sodium