Effects of hOGG1 Associated with the Aging Process on the Development of Benign Prostatic Hyperplasia

Eom, Min Sik; Kim, Yong Tae; Kim, Wun Jae

Abstract

PURPOSE
8-oxoguanine DNA glycosylase (OGG) repairs DNA by removing 8-oxoguanine (oh8Gua), a highly mutagenic oxidative DNA adduct. Recently, the human gene for OGG (hOGG1) was cloned and several genotypes have been reported. However, the implications of such genotypes in benign prostatic hyperplasia (BPH) have not been demonstrated. To assess the involvement of hOGG1 associated with the aging process on the development of BPH, we analyzed the genetic polymorphisms of hOGG1.
MATERIALS AND METHODS
In 162 cases of BPH and 162 normal controls we studied the hOGG1 gene polymorphisms by performing genotype studies to characterize the genetic polymorphisms of hOGG1.
RESULTS
We found a polymorphism at codon 326 in exon 7. The distribution of hOGG1 genotypes at codon 326 in BPH patients (Ser326Ser type, 18.5%; Ser326Cys type, 42.0%; and Cys326Cys type, 39.5%) was significantly different from that in the controls (14.8%, 63.0% and 22.2%, respectively) (p=0.022). Homozygosity for the Cys326Cys genotype significantly increased the risk of developing BPH, with the odds ratio (OR) being 2.286 (95% confidence interval [CI]=1.149-4.546).
CONCLUSIONS
Our results suggest that the hOGG1 Cys326Cys genotype might play an important role in the development of BPH.