J Korean Acad Child Adolesc Psychiatry.
2011 Dec;22(4):287-293.
Polymorphisms of CDH9 and CDH10 in Chromosome 5p14 Associatedwith Autism in the Korean Population
- Affiliations
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- 1Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea. kbkwack@cha.ac.kr
- 2Department of Psychiatry, Seoul Metropolitan Children's Hospital, Seoul, Korea.
- 3Department of Psychology, College of Social Science, Ewha Womans University, Seoul, Korea.
- 4Department of Neuropsychiatry, College of Medicine, Korea University, Seoul, Korea.
- 5Department of Elementary Special Education, College of Social Science, Joongbu University, Geumsan, Korea.
- 6Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
Abstract
OBJECTIVES
The region of chromosome 5p14 is known to be associated with autism spectrum disorder (ASD). The cadherin9 (CDH9) and cadherin10 (CDH10) genes are located in the region of chromosome 5p14 and reported to be associated with ASD in the Caucasian population. We performed an association study to identify if single nucleotide polymorphisms (SNPs) located on the CDH9 and CDH10 genes are associated in the Korean population.
METHODS
Genomic DNA was extracted from the blood of 214 patients with ASD and 258 controls. SNPs selected from two genes were genotyped using an Illumina Golden-Gate Genotyping assay with VeraCode technology. Statistical analysis was performed using SAS and Plink software.
RESULTS
All controls and ASD patients were in Hardy-Weinberg equilibrium. In the results of logistic regression analyses for the genotype model and the chi-square test for the allele model, we found that SNPs on the CDH9 and CDH10 genes were not associated with ASD.
CONCLUSION
Our data suggests that the CDH9 and CDH10 genes are not associated with ASD in the Korean population.
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