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Spatial Learning and Motor Deficits in Vacuolar Protein Sorting-associated Protein 13b (Vps13b) Mutant Mouse

Kim MJ, Lee RU, Oh J, Choi JE, Kim H, Lee K, Hwang SK, Lee JH, Lee JA, Kaang BK, Lim CS, Lee YS

Vacuolar protein sorting-associated protein 13B (VPS13B), also known as COH1, is one of the VPS13 family members which is involved in transmembrane transport, Golgi integrity, and neuritogenesis. Mutations in the...
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Clinical Usefulness of the Korean Developmental Screening Test (K-DST) for Developmental Delays

Jang CH, Kim SW, Jeon HR, Jung DW, Cho HE, Kim J, Lee JW

OBJECTIVE: To evaluate the clinical usefulness of the Korean Developmental Screening Test (K-DST) via comparison with Korean Ages and Stages Questionnaire (K-ASQ) for the diagnosis of developmental delay in pediatric...
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Levels of Salivary Sialic Acid in Children with Autism Spectrum Disorder; Could It Be Related to Stereotypes and Hyperactivity?

Demirci E, Guler Y, Ozmen S, Canpolat M, Kumandas S

OBJECTIVE: Sialic acid (Sia) is an essential nutrient for brain development, learning, memory and cognition and plays a role in neurodevelopment of infants. The aim of this study was to...
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Screening Instruments for Autism Spectrum Disorder: Mini Review

Lee N, Hong Y, Kim Y

Most screening instruments for autism spectrum disorder (ASD) have been developed and evaluated in western countries. Therefore, difficulties are often experienced when using these instruments because of the cultural differences...
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Effects of Therapeutic Horseback Riding on Cognition and Language in Children With Autism Spectrum Disorder or Intellectual Disability: A Preliminary Study

Kwon S, Sung IY, Ko EJ, Kim HS

OBJECTIVE: To investigate if therapeutic horseback riding (THR) can improve language and cognitive function in children with autism spectrum disorder (ASD) or intellectual disability (ID). METHODS: We conducted a prospective case-control...
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Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum

Lee Y, Han PL

A number of specific genetic variants including gene mutations and single nucleotide variations have been identified in genomewide association studies of autism spectrum disorder (ASD). ASD phenotypes in individuals carrying...
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Polymorphisms of Ionotropic Glutamate Receptor-Related Genes and the Risk of Autism Spectrum Disorder in a Chinese Population

Xie X, Hou F, Li L, Chen Y, Liu L, Luo X, Gu H, Li X, Zhang J, Gong J, Song R

OBJECTIVE: To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population. METHODS: We performed spatio-temporal expression analysis of GRIK2 and NLGN1 in the developing prefrontal...
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Chromosomal Microarray Analysis as a First-Tier Clinical Diagnostic Test in Patients With Developmental Delay/Intellectual Disability, Autism Spectrum Disorders, and Multiple Congenital Anomalies: A Prospective Multicenter Study in Korea

Jang W, Kim Y, Han E, Park J, Chae H, Kwon A, Choi H, Kim J, Son JO, Lee SJ, Hong BY, Jang DH, Han JY, Lee JH, Kim SY, Lee IG, Sung IK, Moon Y, Kim M, Park JH

BACKGROUND: To validate the clinical application of chromosomal microarray analysis (CMA) as a first-tier clinical diagnostic test and to determine the impact of CMA results on patient clinical management, we...
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The association between preeclampsia and autism spectrum disorders among children: a meta-analysis

Jenabi E, Karami M, Khazaei S, Bashirian

PURPOSE: In this meta-analysis, relevant case-control and cohort studies were pooled to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children. METHODS: A search for...
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White Matter Tract-Cognitive Relationships in Children with High-Functioning Autism Spectrum Disorder

Kato Y, Kagitani-Shimono K, Matsuzaki , Hanaie R, Yamamoto T, Tominaga K, Watanabe Y, Mohri I, Taniike M

OBJECTIVE: The purpose of the present study was to clarify the relationship between white matter tracts and cognitive symptoms in children with high-functioning autism spectrum disorder (ASD). METHODS: We examined the...
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Mental Health Literacy of Autism Spectrum Disorder in Korea: Recognition, Etiology, Treatment

Rim SJ, Park S, Lee Y, Kim CE

OBJECTIVE: The objective of this study was to investigate the Korean public’s recognition of autism spectrum disorder (ASD), revealing underlying factors regarding perception relative to etiology and treatment of ASD,...
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Evaluation of drug interventions for the treatment of sleep disorders in children with autism spectrum disorders: a systematic review

Jenabi E, Ataei S, Bashirian

A structured review study of drug interventions on sleep disorders in patients with autism spectrum disorders (ASD) has not been published to date. This systematic review aimed to investigate drug...
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Down the Rabbit Hole-Considerations for Ingested Foreign Bodies

Brown J, Kidder M, Fabbrini A, deVries J, Robertson , Chandler N, Wilsey M

We report the case of a seven-year-old boy with an ingested foreign body, which was retained within the appendix for a known duration of ten months, ultimately requiring appendectomy. The...
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Comparison of Services for Autism Spectrum Disorder in Massachusetts with Those in Seoul

Kim JW, Kim HW, Moon DS, Lim YS, McDougle C, Howe YJ

BACKGROUND: This article intended to identify and describe areas in need of services and interventions for individuals with autism spectrum disorder (ASD) and their families in Seoul, Korea. METHODS: A descriptive...
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The Use of Artificial Intelligence in Screening and Diagnosis of Autism Spectrum Disorder: A Literature Review

Song DY, Kim SY, Bong G, Kim JM, Yoo HJ

  • KMID: 2464246
  • J Korean Acad Child Adolesc Psychiatry.
  • 2019 Oct;30(4):145-152.
  • doi: 10.5765/jkacap.190027
OBJECTIVES: The detection of autism spectrum disorder (ASD) is based on behavioral observations. To build a more objective data-driven method for screening and diagnosing ASD, many studies have attempted to...
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Review of Early Intervention for Children with Autism Spectrum Disorder: Focused on Randomized Controlled Trials

Yang YH

  • KMID: 2464245
  • J Korean Acad Child Adolesc Psychiatry.
  • 2019 Oct;30(4):136-144.
  • doi: 10.5765/jkacap.180035
Early identification and intervention for autism spectrum disorder (ASD) were reported to be important for outcomes or clinical courses. However, there have been a few robust evidences for effectiveness of...
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A Validation Study of the Korean Child Behavior Checklist 1.5-5 in the Diagnosis of Autism Spectrum Disorder and Non-Autism Spectrum Disorder

Cho HN, Ha EH

OBJECTIVES: The purpose of this study was to analyze the discriminant validity and the clinical cut off scores of the Child Behavior Checklist 1.5-5 (CBCL 1.5-5) in the diagnosis of...
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Aberrant Neural Activation Underlying Idiom Comprehension in Korean Children with High Functioning Autism Spectrum Disorder

Kim N, Choi US, Ha S, Lee SB, Song SH, Song DH, Cheon KA

PURPOSE: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication impairments and repetitive behaviors or restricted interests. Impaired pragmatic language comprehension is a universal feature in individuals...
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T-Type Calcium Channels Are Required to Maintain Viability of Neural Progenitor Cells

Kim JW, Oh HA, Lee SH, Kim KC, Eun PH, Ko MJ, Gonzales E, Seung H, Kim S, Bahn GH, Shin CY

T-type calcium channels are low voltage-activated calcium channels that evoke small and transient calcium currents. Recently, T-type calcium channels have been implicated in neurodevelopmental disorders such as autism spectrum disorder...
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Microglia and Autism Spectrum Disorder: Overview of Current Evidence and Novel Immunomodulatory Treatment Options

Kim JW, Hong JY, Bae SM

Autism spectrum disorder is a rapidly increasing heterogeneous neurodevelopmental syndrome, remarked by persistent deficit in social communication, and restricted, repetitive patterns of behavior and interest. Lately, maternal immune activation and...
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